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Comprehensive Multiplatform Tyrosine Kinase Profiling Reveals Novel Actionable FGFR Aberrations across Sarcomas Affecting the Young.

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Title: Comprehensive Multiplatform Tyrosine Kinase Profiling Reveals Novel Actionable FGFR Aberrations across Sarcomas Affecting the Young.
Authors: Fordham AM; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Brown LM; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Mayoh C; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Salib A; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Barger ZA; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Wong M; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Lim Kam Sian TCC; Cancer Program, Monash Biomedicine Discovery Institute, Clayton, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia., Hu C; Cancer Program, Monash Biomedicine Discovery Institute, Clayton, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia.; Wenzhou Medical University-Monash BDI Alliance in Clinical and Experimental Biomedicine, Wenzhou Medical University, Wenzhou, China., Xie J; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Gunther K; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Trebilcock P; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Terry RL; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Barahona P; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Ajuyah P; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Sherstyuk A; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Avila A; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Cadiz R; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Perkins CM; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Gifford AJ; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.; Anatomical Pathology, NSW Health Pathology, Prince of Wales Hospital, Randwick, Australia., Mao J; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Dolman MEM; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Zhao A; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., O'Regan LP; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Gorgels D; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Lau LMS; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.; Kids Cancer Centre, Sydney Children's Hospital, Randwick Australia., Ziegler DS; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.; Kids Cancer Centre, Sydney Children's Hospital, Randwick Australia., Haber M; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Tyrrell V; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Lock RB; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.; UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, Australia., Cowley MJ; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia., Nicholls W; Oncology Services Group, Queensland Children's Hospital, South Brisbane, Australia.; Faculty of Medicine, The University of Queensland, Brisbane, Australia., Daly RJ; Cancer Program, Monash Biomedicine Discovery Institute, Clayton, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia., Ekert PG; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.; UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, Australia.; Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.; Peter MacCallum Cancer Centre, Melbourne, Australia., Fleuren EDG; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.; UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, Australia.
Source: Molecular cancer therapeutics [Mol Cancer Ther] 2026 Apr 27, pp. OF1-OF18. Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE
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  Data: Comprehensive Multiplatform Tyrosine Kinase Profiling Reveals Novel Actionable FGFR Aberrations across Sarcomas Affecting the Young.
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  Data: <searchLink fieldCode="AU" term="%22Fordham+AM%22">Fordham AM</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Brown+LM%22">Brown LM</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Mayoh+C%22">Mayoh C</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Salib+A%22">Salib A</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Barger+ZA%22">Barger ZA</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Wong+M%22">Wong M</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Lim+Kam+Sian+TCC%22">Lim Kam Sian TCC</searchLink>; Cancer Program, Monash Biomedicine Discovery Institute, Clayton, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Hu+C%22">Hu C</searchLink>; Cancer Program, Monash Biomedicine Discovery Institute, Clayton, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia.; Wenzhou Medical University-Monash BDI Alliance in Clinical and Experimental Biomedicine, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Xie+J%22">Xie J</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Gunther+K%22">Gunther K</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Trebilcock+P%22">Trebilcock P</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Terry+RL%22">Terry RL</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Barahona+P%22">Barahona P</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Ajuyah+P%22">Ajuyah P</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Sherstyuk+A%22">Sherstyuk A</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Avila+A%22">Avila A</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Cadiz+R%22">Cadiz R</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Perkins+CM%22">Perkins CM</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Gifford+AJ%22">Gifford AJ</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.; Anatomical Pathology, NSW Health Pathology, Prince of Wales Hospital, Randwick, Australia.<br /><searchLink fieldCode="AU" term="%22Mao+J%22">Mao J</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Dolman+MEM%22">Dolman MEM</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Zhao+A%22">Zhao A</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22O'Regan+LP%22">O'Regan LP</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Gorgels+D%22">Gorgels D</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Lau+LMS%22">Lau LMS</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.; Kids Cancer Centre, Sydney Children's Hospital, Randwick Australia.<br /><searchLink fieldCode="AU" term="%22Ziegler+DS%22">Ziegler DS</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.; Kids Cancer Centre, Sydney Children's Hospital, Randwick Australia.<br /><searchLink fieldCode="AU" term="%22Haber+M%22">Haber M</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Tyrrell+V%22">Tyrrell V</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; 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Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Ekert+PG%22">Ekert PG</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.; UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, Australia.; Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.; Peter MacCallum Cancer Centre, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Fleuren+EDG%22">Fleuren EDG</searchLink>; Children's Cancer Institute , Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, Australia.; UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, Australia.
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