Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway.
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| Title: | Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway. |
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| Authors: | Baraka SM; Chemistry of Natural Compounds Department, National Research Centre, Giza, 12622, Egypt. sarascience11@yahoo.com., El-Gendy ZA; Department of Pharmacology, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Giza, Egypt., El-Abd EAW; Pharmacognosy Department, National Research Centre (NRC), El Behouth St., P.O. 12622, Cairo, Egypt., El-Sayed AF; Microbial Genetics Department, Biotechnology Research Institute, National Research Centre, Dokki, Giza, 12622, Egypt.; Egypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt., Omara EA; Pathology Department, National Research Centre, Dokki, Cairo, Egypt., Elbatanony MM; Pharmacognosy Department, National Research Centre (NRC), El Behouth St., P.O. 12622, Cairo, Egypt. |
| Source: | Inflammopharmacology [Inflammopharmacology] 2026 Jun; Vol. 34 (6), pp. 4197-4218. Date of Electronic Publication: 2026 Apr 27. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9112626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5608 (Electronic) Linking ISSN: 09254692 NLM ISO Abbreviation: Inflammopharmacology Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1568-5608 |
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| DOI: | 10.1007/s10787-026-02245-y |
