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Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles.

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Title: Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles.
Authors: Goh KY; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore., Lee WX; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore., Gou Q; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore., Choy SM; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore., Ong SC; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore., Gopal Krishnan PD; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore., Wang H; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.; Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China., Turqueza LRR; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore., Tan QH; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore., Chua K; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.; Department of Orthopaedic Surgery, Singapore General Hospital, Singapore, Singapore.; Programme in Musculoskeletal Sciences Academic Clinical Program, SingHealth/Duke-NUS, Singapore, Singapore., Li S; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore., Nishiyama J; Program in Neuroscience and Behavioural Disorders, Duke-NUS Medical School, Singapore, Singapore., Harmston N; Molecular Biosciences Division, Cardiff School of Biosciences, Cardiff University, Cardiff, UK., Tang HW; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore. hongwen.tang@duke-nus.edu.sg.
Source: Nature communications [Nat Commun] 2026 Apr 27; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles.
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  Data: <searchLink fieldCode="AU" term="%22Goh+KY%22">Goh KY</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+WX%22">Lee WX</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Gou+Q%22">Gou Q</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Choy+SM%22">Choy SM</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ong+SC%22">Ong SC</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Gopal+Krishnan+PD%22">Gopal Krishnan PD</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.; Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.<br /><searchLink fieldCode="AU" term="%22Turqueza+LRR%22">Turqueza LRR</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+QH%22">Tan QH</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chua+K%22">Chua K</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.; Department of Orthopaedic Surgery, Singapore General Hospital, Singapore, Singapore.; Programme in Musculoskeletal Sciences Academic Clinical Program, SingHealth/Duke-NUS, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Nishiyama+J%22">Nishiyama J</searchLink>; Program in Neuroscience and Behavioural Disorders, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Harmston+N%22">Harmston N</searchLink>; Molecular Biosciences Division, Cardiff School of Biosciences, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Tang+HW%22">Tang HW</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore. hongwen.tang@duke-nus.edu.sg.
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