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Hepatic FGF21 is not required for fasting metabolism but guides protein appetite post energy depletion.

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Title: Hepatic FGF21 is not required for fasting metabolism but guides protein appetite post energy depletion.
Authors: Bruse J; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France., Marbach C; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France.; Service de Gastroentérologie, Hépatologie, Nutrition et Maladies Héréditaires du Métabolisme pédiatriques, Hôpital des Enfants, CHU de Toulouse, 31059, Toulouse, France., Polizzi A; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France., Landre T; Centre des Sciences et du Goût et de l'Alimentation (CSGA), UMR CNRS 6265, INRAE 1324, Institut Agro, Université de Bourgogne, 21000, Dijon, France., Salvi J; Centre des Sciences et du Goût et de l'Alimentation (CSGA), UMR CNRS 6265, INRAE 1324, Institut Agro, Université de Bourgogne, 21000, Dijon, France., Alquier-Bacquie V; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France., Chen SP; Université Paris Cité, Unité de Biologie Fonctionnelle et Adaptative (BFA), CNRS, UMR8251, 75013, Paris, France., Huillet M; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France., Rives C; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France., Martin CMP; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France., Perrier P; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France., Benhamed F; Université de Paris Cité, Institut Cochin, CNRS, INSERM, 75014, Paris, France., Régnier M; Université de Paris Cité, Institut Cochin, CNRS, INSERM, 75014, Paris, France., Weger S; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Virology, Campus Benjamin Franklin, Berlin, Germany., Naylies C; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France., Lippi Y; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France., Sommer C; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France., Albin M; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France., Lasserre F; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France., Levade T; Univ Toulouse, INSERM, Cancer Research Center of Toulouse (CRCT), 31100, Toulouse, France.; Laboratoire de Biochimie, Institut Fédératif de Biologie, CHU Purpan, 31059, Toulouse, France., Schupp M; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Pharmacology, Cardiovascular Metabolic Renal (CMR)-Research Center, Berlin, Germany., Gamet-Payrastre L; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France., Kautz L; Institut de Recherche en Santé Digestive (IRSD), INSERM U1220, Université de Toulouse, INRAE, ENVT, 31300, Toulouse, France., Loiseau N; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France., Wahli W; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France.; Center for Integrative Genomics, Université de Lausanne, CH-1015, Lausanne, Switzerland., Ellero-Simatos S; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France., Cruciani-Guglielmacci C; Université Paris Cité, Unité de Biologie Fonctionnelle et Adaptative (BFA), CNRS, UMR8251, 75013, Paris, France., Montagner A; Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), INSERM, 31400, Toulouse, France., Benani A; Centre des Sciences et du Goût et de l'Alimentation (CSGA), UMR CNRS 6265, INRAE 1324, Institut Agro, Université de Bourgogne, 21000, Dijon, France., Postic C; Université de Paris Cité, Institut Cochin, CNRS, INSERM, 75014, Paris, France., Guillou H; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France. herve.guillou@inrae.fr., Fougerat A; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France. anne.fougerat@inrae.fr.
Source: EMBO reports [EMBO Rep] 2026 Jun; Vol. 27 (12), pp. 3189-3213. Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Hepatic FGF21 is not required for fasting metabolism but guides protein appetite post energy depletion.
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Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Pharmacology, Cardiovascular Metabolic Renal (CMR)-Research Center, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Gamet-Payrastre+L%22">Gamet-Payrastre L</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Kautz+L%22">Kautz L</searchLink>; Institut de Recherche en Santé Digestive (IRSD), INSERM U1220, Université de Toulouse, INRAE, ENVT, 31300, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Loiseau+N%22">Loiseau N</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Wahli+W%22">Wahli W</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France.; Center for Integrative Genomics, Université de Lausanne, CH-1015, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ellero-Simatos+S%22">Ellero-Simatos S</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Cruciani-Guglielmacci+C%22">Cruciani-Guglielmacci C</searchLink>; Université Paris Cité, Unité de Biologie Fonctionnelle et Adaptative (BFA), CNRS, UMR8251, 75013, Paris, France.<br /><searchLink fieldCode="AU" term="%22Montagner+A%22">Montagner A</searchLink>; Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), INSERM, 31400, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Benani+A%22">Benani A</searchLink>; Centre des Sciences et du Goût et de l'Alimentation (CSGA), UMR CNRS 6265, INRAE 1324, Institut Agro, Université de Bourgogne, 21000, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Postic+C%22">Postic C</searchLink>; Université de Paris Cité, Institut Cochin, CNRS, INSERM, 75014, Paris, France.<br /><searchLink fieldCode="AU" term="%22Guillou+H%22">Guillou H</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France. herve.guillou@inrae.fr.<br /><searchLink fieldCode="AU" term="%22Fougerat+A%22">Fougerat A</searchLink>; Toxalim (Research Center in Food Toxicology), INRAE UMR 1331, ENVT, INP-Purpan, Université de Toulouse, 31300, Toulouse, France. anne.fougerat@inrae.fr.
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