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Deep learning-driven prediction of on-target activity, off-target risk, and repair outcomes in CRISPR/Cas9: current landscape and multi-scale perspectives.

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Title: Deep learning-driven prediction of on-target activity, off-target risk, and repair outcomes in CRISPR/Cas9: current landscape and multi-scale perspectives.
Authors: Du W; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, China.; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, 510632, China.; Gene Editing Technology Center of Guangdong Province, School of Medicine, Foshan University, Foshan, Guangdong, 528225, China., Zhang T; Division of Breast Surgery, Department of General Surgery, Shenzhen People's Hospital, (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, 518020, China., Guo L; Gene Editing Technology Center of Guangdong Province, School of Medicine, Foshan University, Foshan, Guangdong, 528225, China., Zheng Y; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, China.; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, 510632, China.; Gene Editing Technology Center of Guangdong Province, School of Medicine, Foshan University, Foshan, Guangdong, 528225, China., Zhang H; Department of Experimental Medical Science, Lund University, Lund, Sweden., Zhu X; Gene Editing Technology Center of Guangdong Province, School of Medicine, Foshan University, Foshan, Guangdong, 528225, China., Tang D; Gene Editing Technology Center of Guangdong Province, School of Medicine, Foshan University, Foshan, Guangdong, 528225, China., Hu H; Division of Breast Surgery, Department of General Surgery, Shenzhen People's Hospital, (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, 518020, China. chris_huhong@hotmail.com., Chen L; Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China. lingpzy@163.com., Liu C; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, China. liuchaogzf@163.com.; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, 510632, China. liuchaogzf@163.com.
Source: Journal of translational medicine [J Transl Med] 2026 Apr 28; Vol. 24 (1). Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article; Review
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Deep learning-driven prediction of on-target activity, off-target risk, and repair outcomes in CRISPR/Cas9: current landscape and multi-scale perspectives.
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  Data: <searchLink fieldCode="AU" term="%22Du+W%22">Du W</searchLink>; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, China.; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, 510632, China.; Gene Editing Technology Center of Guangdong Province, School of Medicine, Foshan University, Foshan, Guangdong, 528225, China.<br /><searchLink fieldCode="AU" term="%22Zhang+T%22">Zhang T</searchLink>; Division of Breast Surgery, Department of General Surgery, Shenzhen People's Hospital, (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, 518020, China.<br /><searchLink fieldCode="AU" term="%22Guo+L%22">Guo L</searchLink>; Gene Editing Technology Center of Guangdong Province, School of Medicine, Foshan University, Foshan, Guangdong, 528225, China.<br /><searchLink fieldCode="AU" term="%22Zheng+Y%22">Zheng Y</searchLink>; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, China.; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, 510632, China.; Gene Editing Technology Center of Guangdong Province, School of Medicine, Foshan University, Foshan, Guangdong, 528225, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Experimental Medical Science, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Zhu+X%22">Zhu X</searchLink>; Gene Editing Technology Center of Guangdong Province, School of Medicine, Foshan University, Foshan, Guangdong, 528225, China.<br /><searchLink fieldCode="AU" term="%22Tang+D%22">Tang D</searchLink>; Gene Editing Technology Center of Guangdong Province, School of Medicine, Foshan University, Foshan, Guangdong, 528225, China.<br /><searchLink fieldCode="AU" term="%22Hu+H%22">Hu H</searchLink>; Division of Breast Surgery, Department of General Surgery, Shenzhen People's Hospital, (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, 518020, China. chris_huhong@hotmail.com.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China. lingpzy@163.com.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, China. liuchaogzf@163.com.; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou, 510632, China. liuchaogzf@163.com.
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        Value: 10.1186/s12967-026-08175-1
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      – Code: eng
        Text: English
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      – TitleFull: Deep learning-driven prediction of on-target activity, off-target risk, and repair outcomes in CRISPR/Cas9: current landscape and multi-scale perspectives.
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              Text: 2026 Apr 28
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