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Adjuvant recombinant human endostatin combined with toripalimab (anti-PD-1) in locally advanced melanoma: an exploratory phase 2 clinical trial incorporating single-cell RNA/TCR/BCR sequencing.

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Title: Adjuvant recombinant human endostatin combined with toripalimab (anti-PD-1) in locally advanced melanoma: an exploratory phase 2 clinical trial incorporating single-cell RNA/TCR/BCR sequencing.
Authors: Hu X; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Xu Y; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Wang Z; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Yang L; Department of Oncology, Yueyang People's Hospital of Hunan Normal University, Yueyang, China., Zheng B; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Sun F; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Liu D; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Shi B; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Zheng H; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Liu X; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China., Yu L; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China., Zhang S; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.; Department of Radiology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China., Yan Y; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Yan W; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China. yanwj@fudan.edu.cn.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. yanwj@fudan.edu.cn., Sun Y; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China., Chen Y; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China. chenyong@fudan.edu.cn.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. chenyong@fudan.edu.cn., Wang C; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China. cmwang_gr@fudan.edu.cn.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. cmwang_gr@fudan.edu.cn.
Source: Molecular cancer [Mol Cancer] 2026 Apr 27; Vol. 25 (1). Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article; Clinical Trial, Phase II
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Adjuvant recombinant human endostatin combined with toripalimab (anti-PD-1) in locally advanced melanoma: an exploratory phase 2 clinical trial incorporating single-cell RNA/TCR/BCR sequencing.
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  Data: <searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Department of Oncology, Yueyang People's Hospital of Hunan Normal University, Yueyang, China.<br /><searchLink fieldCode="AU" term="%22Zheng+B%22">Zheng B</searchLink>; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Sun+F%22">Sun F</searchLink>; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Liu+D%22">Liu D</searchLink>; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Shi+B%22">Shi B</searchLink>; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zheng+H%22">Zheng H</searchLink>; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yu+L%22">Yu L</searchLink>; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.; Department of Radiology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yan+Y%22">Yan Y</searchLink>; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yan+W%22">Yan W</searchLink>; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China. yanwj@fudan.edu.cn.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. yanwj@fudan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China. chenyong@fudan.edu.cn.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. chenyong@fudan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China. cmwang_gr@fudan.edu.cn.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. cmwang_gr@fudan.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101147698%22">Molecular cancer</searchLink> [Mol Cancer] 2026 Apr 27; Vol. 25 (1). <i>Date of Electronic Publication: </i>2026 Apr 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101147698 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-4598 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214764598%22">14764598 </searchLink><i>NLM ISO Abbreviation: </i>Mol Cancer <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12943-026-02675-w
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        Text: English
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      – TitleFull: Adjuvant recombinant human endostatin combined with toripalimab (anti-PD-1) in locally advanced melanoma: an exploratory phase 2 clinical trial incorporating single-cell RNA/TCR/BCR sequencing.
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              Text: 2026 Apr 27
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