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Concurrent P-Selectin Targeting Nanoparticle Orchestrates Tumor-Immune Dynamics for Advanced Immunochemotherapy.

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Title: Concurrent P-Selectin Targeting Nanoparticle Orchestrates Tumor-Immune Dynamics for Advanced Immunochemotherapy.
Authors: Lee W; Cell Therapy Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan., Lin SL; Translational Medicine Research Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404328, Taiwan., Chen JY; Translational Medicine Research Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan., Huang BJ; Translational Medicine Research Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan., Chieng WW; Translational Medicine Research Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan., Tsai IJ; Cell Therapy Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan., Chang TY; Cell Therapy Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan., Lai YH; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu 310401, Taiwan., Hong WZ; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404328, Taiwan., Huang KC; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung 404328, Taiwan.; Translation Research Core, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung 404328, Taiwan.; Office of Research and Development, Asia University, Taichung 413305, Taiwan., Hung MC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404328, Taiwan.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung 404328, Taiwan.; Molecular Medicine Center, China Medical University Hospital, Taichung 404327, Taiwan., Chen SY; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404328, Taiwan.; Department of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu 300093, Taiwan., Jeng LB; Cell Therapy Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.; Organ Transplantation Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan., Shyu WC; Translational Medicine Research Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404328, Taiwan.; Office of Research and Development, Asia University, Taichung 413305, Taiwan.; Neuroscience and Brain Disease Center and New Drug Development Center, China Medical University, Taichung 404328, Taiwan.; Department of Neurology, China Medical University Hospital, Taichung 404327, Taiwan.; Department of Occupational Therapy, Asia University, Taichung 413305, Taiwan., Chiang CS; Cell Therapy Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404328, Taiwan.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung 404328, Taiwan.; Office of Research and Development, Asia University, Taichung 413305, Taiwan.; Neuroscience and Brain Disease Center and New Drug Development Center, China Medical University, Taichung 404328, Taiwan.
Source: ACS nano [ACS Nano] 2026 May 12; Vol. 20 (18), pp. 13496-13516. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Concurrent P-Selectin Targeting Nanoparticle Orchestrates Tumor-Immune Dynamics for Advanced Immunochemotherapy.
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  Data: <searchLink fieldCode="AU" term="%22Lee+W%22">Lee W</searchLink>; Cell Therapy Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+SL%22">Lin SL</searchLink>; Translational Medicine Research Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404328, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+JY%22">Chen JY</searchLink>; Translational Medicine Research Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+BJ%22">Huang BJ</searchLink>; Translational Medicine Research Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chieng+WW%22">Chieng WW</searchLink>; Translational Medicine Research Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+IJ%22">Tsai IJ</searchLink>; Cell Therapy Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+TY%22">Chang TY</searchLink>; Cell Therapy Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lai+YH%22">Lai YH</searchLink>; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu 310401, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hong+WZ%22">Hong WZ</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404328, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+KC%22">Huang KC</searchLink>; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung 404328, Taiwan.; Translation Research Core, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung 404328, Taiwan.; Office of Research and Development, Asia University, Taichung 413305, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hung+MC%22">Hung MC</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404328, Taiwan.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung 404328, Taiwan.; Molecular Medicine Center, China Medical University Hospital, Taichung 404327, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+SY%22">Chen SY</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404328, Taiwan.; Department of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu 300093, Taiwan.<br /><searchLink fieldCode="AU" term="%22Jeng+LB%22">Jeng LB</searchLink>; Cell Therapy Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.; Organ Transplantation Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.<br /><searchLink fieldCode="AU" term="%22Shyu+WC%22">Shyu WC</searchLink>; Translational Medicine Research Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404328, Taiwan.; Office of Research and Development, Asia University, Taichung 413305, Taiwan.; Neuroscience and Brain Disease Center and New Drug Development Center, China Medical University, Taichung 404328, Taiwan.; Department of Neurology, China Medical University Hospital, Taichung 404327, Taiwan.; Department of Occupational Therapy, Asia University, Taichung 413305, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiang+CS%22">Chiang CS</searchLink>; Cell Therapy Center, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404328, Taiwan.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung 404328, Taiwan.; Office of Research and Development, Asia University, Taichung 413305, Taiwan.; Neuroscience and Brain Disease Center and New Drug Development Center, China Medical University, Taichung 404328, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101313589%22">ACS nano</searchLink> [ACS Nano] 2026 May 12; Vol. 20 (18), pp. 13496-13516. <i>Date of Electronic Publication: </i>2026 Apr 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101313589 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1936-086X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219360851%22">19360851 </searchLink><i>NLM ISO Abbreviation: </i>ACS Nano <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1021/acsnano.5c15120
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      – Code: eng
        Text: English
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              Text: 2026 May 12
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