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Clonal Dynamics of Hematopoiesis in Aplastic Anemia after Immunosuppression and Eltrombopag.

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Title: Clonal Dynamics of Hematopoiesis in Aplastic Anemia after Immunosuppression and Eltrombopag.
Authors: Kaya DE; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom., Cook R; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom., Iacobelli S; Department of Public Health and and Infectious Diseases, Università Sapienza of Rome, Rome, Italy.; Severe Aplastic Anemia Working Party, EBMT, Leiden, The Netherlands., Napolitani G; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom., Gerlevik S; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom., Seymen N; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom., Sicre de Fontbrune F; Centre de Référence Aplasie Médullaire, Service d'Hématologie Greffe, Assistance Publique des Hôpitaux de Paris, Hôpital Saint-Louis, Paris, France., Griffin M; Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom., Frieri C; AORN S. Giuseppe Moscati, Avellino, Italy., Halkes CJM; Hematology, Leiden University Medical Center, Leiden, The Netherlands., Recher C; Service d'hématologie, Centre Hospitalo-Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse-Oncopole, Université de Toulouse, Toulouse, France., Barraco F; Service d'Hematologie Clinique, Hôpital Universitaire, Lyon, France., Forcade E; Service d'Hématologie Clinique et Thérapie Cellulaire, CHU Bordeaux, Bordeaux, France., Méar JB; Clinical Hematology, University Hospital of Rennes, Rennes, France., Laurino M; UO Ematologia e Terapie Cellulari, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Drexler B; Department of Hematology, University Hospital Basel, Basel, Switzerland., Daguindau E; Department of Clinical Hematology, University Hospital of Besançon, Besançon, France., van Os M; EBMT Clinical Study Unit, Leiden, The Netherlands., Terwel S; Leiden University, Leiden, The Netherlands., Dufour C; Severe Aplastic Anemia Working Party, EBMT, Leiden, The Netherlands.; IRCCS Institute G. Gaslini Childrens' Hospital, Genova, Italy., Karimi MM; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom., Kulasekararaj AG; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.; Severe Aplastic Anemia Working Party, EBMT, Leiden, The Netherlands.; King's College Hospital-NHS Foundation Trust and NIHR/Wellcome King's Clinical Research Facility, London, United Kingdom., Peffault De Latour R; Severe Aplastic Anemia Working Party, EBMT, Leiden, The Netherlands.; Centre de Référence Aplasie Médullaire, Service d'Hématologie Greffe, Assistance Publique des Hôpitaux de Paris, Hôpital Saint-Louis, Paris, France.; Hôpital Saint-Louis, Paris, France., Risitano AM; Severe Aplastic Anemia Working Party, EBMT, Leiden, The Netherlands.; AORN S. Giuseppe Moscati, Avellino, Italy.; University of Naples, Napoli, Italy., Mufti G; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.
Source: NEJM evidence [NEJM Evid] 2026 May; Vol. 5 (5), pp. EVIDoa2500174. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III
Journal Info: Publisher: NEJM Group, a division of the Massachusetts Medical Society Country of Publication: United States NLM ID: 9918317485806676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2766-5526 (Electronic) Linking ISSN: 27665526 NLM ISO Abbreviation: NEJM Evid Subsets: MEDLINE
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  Data: Clonal Dynamics of Hematopoiesis in Aplastic Anemia after Immunosuppression and Eltrombopag.
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  Data: <searchLink fieldCode="AU" term="%22Kaya+DE%22">Kaya DE</searchLink>; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cook+R%22">Cook R</searchLink>; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Iacobelli+S%22">Iacobelli S</searchLink>; Department of Public Health and and Infectious Diseases, Università Sapienza of Rome, Rome, Italy.; Severe Aplastic Anemia Working Party, EBMT, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Napolitani+G%22">Napolitani G</searchLink>; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gerlevik+S%22">Gerlevik S</searchLink>; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Seymen+N%22">Seymen N</searchLink>; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sicre+de+Fontbrune+F%22">Sicre de Fontbrune F</searchLink>; Centre de Référence Aplasie Médullaire, Service d'Hématologie Greffe, Assistance Publique des Hôpitaux de Paris, Hôpital Saint-Louis, Paris, France.<br /><searchLink fieldCode="AU" term="%22Griffin+M%22">Griffin M</searchLink>; Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Frieri+C%22">Frieri C</searchLink>; AORN S. Giuseppe Moscati, Avellino, Italy.<br /><searchLink fieldCode="AU" term="%22Halkes+CJM%22">Halkes CJM</searchLink>; Hematology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Recher+C%22">Recher C</searchLink>; Service d'hématologie, Centre Hospitalo-Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse-Oncopole, Université de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Barraco+F%22">Barraco F</searchLink>; Service d'Hematologie Clinique, Hôpital Universitaire, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Forcade+E%22">Forcade E</searchLink>; Service d'Hématologie Clinique et Thérapie Cellulaire, CHU Bordeaux, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Méar+JB%22">Méar JB</searchLink>; Clinical Hematology, University Hospital of Rennes, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Laurino+M%22">Laurino M</searchLink>; UO Ematologia e Terapie Cellulari, IRCCS Ospedale Policlinico San Martino, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Drexler+B%22">Drexler B</searchLink>; Department of Hematology, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Daguindau+E%22">Daguindau E</searchLink>; Department of Clinical Hematology, University Hospital of Besançon, Besançon, France.<br /><searchLink fieldCode="AU" term="%22van+Os+M%22">van Os M</searchLink>; EBMT Clinical Study Unit, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Terwel+S%22">Terwel S</searchLink>; Leiden University, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Dufour+C%22">Dufour C</searchLink>; Severe Aplastic Anemia Working Party, EBMT, Leiden, The Netherlands.; IRCCS Institute G. Gaslini Childrens' Hospital, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Karimi+MM%22">Karimi MM</searchLink>; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kulasekararaj+AG%22">Kulasekararaj AG</searchLink>; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.; Severe Aplastic Anemia Working Party, EBMT, Leiden, The Netherlands.; King's College Hospital-NHS Foundation Trust and NIHR/Wellcome King's Clinical Research Facility, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Peffault+De+Latour+R%22">Peffault De Latour R</searchLink>; Severe Aplastic Anemia Working Party, EBMT, Leiden, The Netherlands.; Centre de Référence Aplasie Médullaire, Service d'Hématologie Greffe, Assistance Publique des Hôpitaux de Paris, Hôpital Saint-Louis, Paris, France.; Hôpital Saint-Louis, Paris, France.<br /><searchLink fieldCode="AU" term="%22Risitano+AM%22">Risitano AM</searchLink>; Severe Aplastic Anemia Working Party, EBMT, Leiden, The Netherlands.; AORN S. Giuseppe Moscati, Avellino, Italy.; University of Naples, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Mufti+G%22">Mufti G</searchLink>; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.
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  Data: <searchLink fieldCode="JN" term="%229918317485806676%22">NEJM evidence</searchLink> [NEJM Evid] 2026 May; Vol. 5 (5), pp. EVIDoa2500174. <i>Date of Electronic Publication: </i>2026 Apr 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22NEJM+Group%2C+a+division+of+the+Massachusetts+Medical+Society%22">NEJM Group, a division of the Massachusetts Medical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9918317485806676 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2766-5526 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2227665526%22">27665526 </searchLink><i>NLM ISO Abbreviation: </i>NEJM Evid <i>Subsets: </i>MEDLINE
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