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Methoxyacetic acid exposure in rats induces N-butyrylglycinuria consistent with beta-oxidation impairment.

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Title: Methoxyacetic acid exposure in rats induces N-butyrylglycinuria consistent with beta-oxidation impairment.
Authors: Sala S; Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA6150, Australia. Samuele.Sala@murdoch.edu.au., Kadyrov J; Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA6150, Australia., Bernal A; Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA6150, Australia., Castillo AM; Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA6150, Australia.; Escuela de Ingeniería de Sistemas y Computación, Universidad del Valle, Cali, 76001, Colombia., Naraprasertkul P; Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wang Lang Rd, Siriraj, Bangkok Noi, Bangkok, 10700, Thailand., Paesalasakul N; Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wang Lang Rd, Siriraj, Bangkok Noi, Bangkok, 10700, Thailand., Bekanan P; Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wang Lang Rd, Siriraj, Bangkok Noi, Bangkok, 10700, Thailand., Dhitsuwon I; Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wang Lang Rd, Siriraj, Bangkok Noi, Bangkok, 10700, Thailand., Kulthawatsiri T; Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA6150, Australia.; The National Phenome Institute, Office of the President, Khon Kaen University, Khon Kaen, 40002, Thailand., Masuda R; Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA6150, Australia., Sharma M; Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA6150, Australia., Phetcharaburanin J; The National Phenome Institute, Office of the President, Khon Kaen University, Khon Kaen, 40002, Thailand.; Department of Systems Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand., Car BD; Formerly Bristol-Myers-Squibb Company, Princeton, NJ, USA., Contreras JIS; Faculty of Medicine, Institute of Global Health Innovation, Imperial College London, Level 1, Faculty Building, South Kensington Campus, London, SW7 2NA, UK., Lindon JC; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College, Burlington Danes Building, Du Cane Road, London, W12 0NN, UK., Wist J; Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA6150, Australia.; Faculty of Medicine, Institute of Global Health Innovation, Imperial College London, Level 1, Faculty Building, South Kensington Campus, London, SW7 2NA, UK.; Departamento de Química, Universidad del Valle, Cali, 76001, Colombia., Nicholson JK; Faculty of Medicine, Institute of Global Health Innovation, Imperial College London, Level 1, Faculty Building, South Kensington Campus, London, SW7 2NA, UK., Holmes E; Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA6150, Australia. Elaine.Holmes@murdoch.edu.au.; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College, Burlington Danes Building, Du Cane Road, London, W12 0NN, UK. Elaine.Holmes@murdoch.edu.au.
Source: Archives of toxicology [Arch Toxicol] 2026 Aug; Vol. 100 (8), pp. 3507-3518. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE; In Process
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  Data: Methoxyacetic acid exposure in rats induces N-butyrylglycinuria consistent with beta-oxidation impairment.
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  Data: <searchLink fieldCode="AU" term="%22Sala+S%22">Sala S</searchLink>; Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA6150, Australia. Samuele.Sala@murdoch.edu.au.<br /><searchLink fieldCode="AU" term="%22Kadyrov+J%22">Kadyrov J</searchLink>; Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA6150, Australia.<br /><searchLink fieldCode="AU" term="%22Bernal+A%22">Bernal A</searchLink>; Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA6150, Australia.<br /><searchLink fieldCode="AU" term="%22Castillo+AM%22">Castillo AM</searchLink>; Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA6150, Australia.; Escuela de Ingeniería de Sistemas y Computación, Universidad del Valle, Cali, 76001, Colombia.<br /><searchLink fieldCode="AU" term="%22Naraprasertkul+P%22">Naraprasertkul P</searchLink>; Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wang Lang Rd, Siriraj, Bangkok Noi, Bangkok, 10700, Thailand.<br /><searchLink fieldCode="AU" term="%22Paesalasakul+N%22">Paesalasakul N</searchLink>; Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wang Lang Rd, Siriraj, Bangkok Noi, Bangkok, 10700, Thailand.<br /><searchLink fieldCode="AU" term="%22Bekanan+P%22">Bekanan P</searchLink>; Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wang Lang Rd, Siriraj, Bangkok Noi, Bangkok, 10700, Thailand.<br /><searchLink fieldCode="AU" term="%22Dhitsuwon+I%22">Dhitsuwon I</searchLink>; Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wang Lang Rd, Siriraj, Bangkok Noi, Bangkok, 10700, Thailand.<br /><searchLink fieldCode="AU" term="%22Kulthawatsiri+T%22">Kulthawatsiri T</searchLink>; Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA6150, Australia.; The National Phenome Institute, Office of the President, Khon Kaen University, Khon Kaen, 40002, Thailand.<br /><searchLink fieldCode="AU" term="%22Masuda+R%22">Masuda R</searchLink>; Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA6150, Australia.<br /><searchLink fieldCode="AU" term="%22Sharma+M%22">Sharma M</searchLink>; Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA6150, Australia.<br /><searchLink fieldCode="AU" term="%22Phetcharaburanin+J%22">Phetcharaburanin J</searchLink>; The National Phenome Institute, Office of the President, Khon Kaen University, Khon Kaen, 40002, Thailand.; Department of Systems Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.<br /><searchLink fieldCode="AU" term="%22Car+BD%22">Car BD</searchLink>; Formerly Bristol-Myers-Squibb Company, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Contreras+JIS%22">Contreras JIS</searchLink>; Faculty of Medicine, Institute of Global Health Innovation, Imperial College London, Level 1, Faculty Building, South Kensington Campus, London, SW7 2NA, UK.<br /><searchLink fieldCode="AU" term="%22Lindon+JC%22">Lindon JC</searchLink>; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College, Burlington Danes Building, Du Cane Road, London, W12 0NN, UK.<br /><searchLink fieldCode="AU" term="%22Wist+J%22">Wist J</searchLink>; Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA6150, Australia.; Faculty of Medicine, Institute of Global Health Innovation, Imperial College London, Level 1, Faculty Building, South Kensington Campus, London, SW7 2NA, UK.; Departamento de Química, Universidad del Valle, Cali, 76001, Colombia.<br /><searchLink fieldCode="AU" term="%22Nicholson+JK%22">Nicholson JK</searchLink>; Faculty of Medicine, Institute of Global Health Innovation, Imperial College London, Level 1, Faculty Building, South Kensington Campus, London, SW7 2NA, UK.<br /><searchLink fieldCode="AU" term="%22Holmes+E%22">Holmes E</searchLink>; Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA6150, Australia. Elaine.Holmes@murdoch.edu.au.; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College, Burlington Danes Building, Du Cane Road, London, W12 0NN, UK. Elaine.Holmes@murdoch.edu.au.
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  Data: <searchLink fieldCode="JN" term="%220417615%22">Archives of toxicology</searchLink> [Arch Toxicol] 2026 Aug; Vol. 100 (8), pp. 3507-3518. <i>Date of Electronic Publication: </i>2026 Apr 28.
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        Value: 10.1007/s00204-026-04330-1
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        Text: English
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