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GLIS3 marks a neural-like progenitor cell state that drives metastasis in pancreatic ductal adenocarcinoma.

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Title: GLIS3 marks a neural-like progenitor cell state that drives metastasis in pancreatic ductal adenocarcinoma.
Authors: Gong D; Center for Systems Biology, Krantz Family Center for Cancer Research, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Program in Health Sciences and Technology, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Guo JA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; School of Medicine, University of California, San Francisco, San Francisco, CA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Su J; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Harvard University, Graduate School of Arts and Sciences, Cambridge, MA, USA., Cetinkaya S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard University, Graduate School of Arts and Sciences, Cambridge, MA, USA., Hennessey C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Yu P; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jambhale A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Grossman School of Medicine, New York University, New York, NY, USA., Wang PL; Center for Systems Biology, Krantz Family Center for Cancer Research, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Caldwell NJ; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Lam A; Center for Systems Biology, Krantz Family Center for Cancer Research, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Surgery and Interventional Science Centre for 3D Models of Health and Disease, and Department of Cell and Developmental Biology Consortium for Mitochondrial Research, University College London, London, UK., Wang J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Shiau C; Center for Systems Biology, Krantz Family Center for Cancer Research, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA., Kapner KS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Dilly J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Abbassi L; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Chugh S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Dasgupta S; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nowak J; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Zhang ML; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Mino-Kenudson M; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Jacks T; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Aguirre AJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: andrew_aguirre@dfci.harvard.edu., Hwang WL; Center for Systems Biology, Krantz Family Center for Cancer Research, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: whwang1@mgh.harvard.edu.
Source: Cell reports [Cell Rep] 2026 May 26; Vol. 45 (5), pp. 117314. Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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  Data: GLIS3 marks a neural-like progenitor cell state that drives metastasis in pancreatic ductal adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Gong+D%22">Gong D</searchLink>; Center for Systems Biology, Krantz Family Center for Cancer Research, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Program in Health Sciences and Technology, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Guo+JA%22">Guo JA</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA; School of Medicine, University of California, San Francisco, San Francisco, CA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Su+J%22">Su J</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Harvard University, Graduate School of Arts and Sciences, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cetinkaya+S%22">Cetinkaya S</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard University, Graduate School of Arts and Sciences, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hennessey+C%22">Hennessey C</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yu+P%22">Yu P</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jambhale+A%22">Jambhale A</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Grossman School of Medicine, New York University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wang+PL%22">Wang PL</searchLink>; Center for Systems Biology, Krantz Family Center for Cancer Research, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Caldwell+NJ%22">Caldwell NJ</searchLink>; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lam+A%22">Lam A</searchLink>; Center for Systems Biology, Krantz Family Center for Cancer Research, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Surgery and Interventional Science Centre for 3D Models of Health and Disease, and Department of Cell and Developmental Biology Consortium for Mitochondrial Research, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shiau+C%22">Shiau C</searchLink>; Center for Systems Biology, Krantz Family Center for Cancer Research, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kapner+KS%22">Kapner KS</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dilly+J%22">Dilly J</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Abbassi+L%22">Abbassi L</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chugh+S%22">Chugh S</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dasgupta+S%22">Dasgupta S</searchLink>; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nowak+J%22">Nowak J</searchLink>; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wolpin+BM%22">Wolpin BM</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+ML%22">Zhang ML</searchLink>; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mino-Kenudson+M%22">Mino-Kenudson M</searchLink>; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jacks+T%22">Jacks T</searchLink>; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Aguirre+AJ%22">Aguirre AJ</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: andrew_aguirre@dfci.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Hwang+WL%22">Hwang WL</searchLink>; Center for Systems Biology, Krantz Family Center for Cancer Research, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: whwang1@mgh.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2026 May 26; Vol. 45 (5), pp. 117314. <i>Date of Electronic Publication: </i>2026 Apr 27.
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