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Mitochondrial double-stranded RNA fuels pancreatic cancer growth via RIG-I/TLR3 inflammation.

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Title: Mitochondrial double-stranded RNA fuels pancreatic cancer growth via RIG-I/TLR3 inflammation.
Authors: Milcarek AT; Genome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104., Yeon M; Genome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104., Esposito C; Genome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104.; Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples 80138, Italy., Kulkarni P; Genome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104., Kossenkov AV; Genome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104.; Bioinformatics Shared Resource, The Wistar Institute, Philadelphia, PA 19104., Madzo J; Genome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104.; Bioinformatics Shared Resource, The Wistar Institute, Philadelphia, PA 19104., Faustino AM; Proteomics Shared Resource, The Wistar Institute, Philadelphia, PA 19104., Tang HY; Proteomics Shared Resource, The Wistar Institute, Philadelphia, PA 19104.; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA 19104., Storaci AM; Department of Pathophysiology and Transplantation, University of Milan, Milan 20122, Italy., Palleschi A; Division of Pathology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda-Ospedale Maggiore, Milano 20122, Italy.; Division of Thoracic Surgery and Lung Transplantation, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda-Ospedale Maggiore Policlinico, Milano 20122, Italy., Locatelli M; Division of Thoracic Surgery and Lung Transplantation, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda-Ospedale Maggiore Policlinico, Milano 20122, Italy.; Division of Neurosurgery, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda-Ospedale Maggiore Policlinico, Milano 20122, Italy., Vaira V; Department of Pathophysiology and Transplantation, University of Milan, Milan 20122, Italy.; Division of Pathology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda-Ospedale Maggiore, Milano 20122, Italy., Iacocca MV; Department of Pathology, Helen F. Graham Cancer Center and Research Institute, Christiana Care Health, Newark, DE 19713.; Helen F. Graham Cancer Center and Research Institute, Christiana Care Health, Newark, DE 19713., Ward A; Department of Pathology, Helen F. Graham Cancer Center and Research Institute, Christiana Care Health, Newark, DE 19713.; Helen F. Graham Cancer Center and Research Institute, Christiana Care Health, Newark, DE 19713., Sabesan A; Helen F. Graham Cancer Center and Research Institute, Christiana Care Health, Newark, DE 19713.; Division of Surgical Oncology, Helen F. Graham Cancer Center and Research Institute, Christiana Care Health, Newark, DE 19713., Petrelli NJ; Helen F. Graham Cancer Center and Research Institute, Christiana Care Health, Newark, DE 19713., Perego M; Genome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104., Altieri DC; Genome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 May 05; Vol. 123 (18), pp. e2528281123. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Mitochondrial double-stranded RNA fuels pancreatic cancer growth via RIG-I/TLR3 inflammation.
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  Data: <searchLink fieldCode="AU" term="%22Milcarek+AT%22">Milcarek AT</searchLink>; Genome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Yeon+M%22">Yeon M</searchLink>; Genome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Esposito+C%22">Esposito C</searchLink>; Genome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104.; Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples 80138, Italy.<br /><searchLink fieldCode="AU" term="%22Kulkarni+P%22">Kulkarni P</searchLink>; Genome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Kossenkov+AV%22">Kossenkov AV</searchLink>; Genome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104.; Bioinformatics Shared Resource, The Wistar Institute, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Madzo+J%22">Madzo J</searchLink>; Genome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104.; Bioinformatics Shared Resource, The Wistar Institute, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Faustino+AM%22">Faustino AM</searchLink>; Proteomics Shared Resource, The Wistar Institute, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Tang+HY%22">Tang HY</searchLink>; Proteomics Shared Resource, The Wistar Institute, Philadelphia, PA 19104.; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Storaci+AM%22">Storaci AM</searchLink>; Department of Pathophysiology and Transplantation, University of Milan, Milan 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Palleschi+A%22">Palleschi A</searchLink>; Division of Pathology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda-Ospedale Maggiore, Milano 20122, Italy.; Division of Thoracic Surgery and Lung Transplantation, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda-Ospedale Maggiore Policlinico, Milano 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Locatelli+M%22">Locatelli M</searchLink>; Division of Thoracic Surgery and Lung Transplantation, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda-Ospedale Maggiore Policlinico, Milano 20122, Italy.; Division of Neurosurgery, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda-Ospedale Maggiore Policlinico, Milano 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Vaira+V%22">Vaira V</searchLink>; Department of Pathophysiology and Transplantation, University of Milan, Milan 20122, Italy.; Division of Pathology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda-Ospedale Maggiore, Milano 20122, Italy.<br /><searchLink fieldCode="AU" term="%22Iacocca+MV%22">Iacocca MV</searchLink>; Department of Pathology, Helen F. Graham Cancer Center and Research Institute, Christiana Care Health, Newark, DE 19713.; Helen F. Graham Cancer Center and Research Institute, Christiana Care Health, Newark, DE 19713.<br /><searchLink fieldCode="AU" term="%22Ward+A%22">Ward A</searchLink>; Department of Pathology, Helen F. Graham Cancer Center and Research Institute, Christiana Care Health, Newark, DE 19713.; Helen F. Graham Cancer Center and Research Institute, Christiana Care Health, Newark, DE 19713.<br /><searchLink fieldCode="AU" term="%22Sabesan+A%22">Sabesan A</searchLink>; Helen F. Graham Cancer Center and Research Institute, Christiana Care Health, Newark, DE 19713.; Division of Surgical Oncology, Helen F. Graham Cancer Center and Research Institute, Christiana Care Health, Newark, DE 19713.<br /><searchLink fieldCode="AU" term="%22Petrelli+NJ%22">Petrelli NJ</searchLink>; Helen F. Graham Cancer Center and Research Institute, Christiana Care Health, Newark, DE 19713.<br /><searchLink fieldCode="AU" term="%22Perego+M%22">Perego M</searchLink>; Genome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Altieri+DC%22">Altieri DC</searchLink>; Genome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104.
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