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Structural rewiring of IL-7R dimerization by an oncogenic transmembrane mutation can be reversed by rational design.

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Title: Structural rewiring of IL-7R dimerization by an oncogenic transmembrane mutation can be reversed by rational design.
Authors: Wang Q; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.; State Key Laboratory of Chemical Biology, Chinese Academy of Sciences, Shanghai 201203, China., Chen M; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China., Lasram A; Department of Biology/Chemistry and Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück 49076, Germany., Vihuri S; Department of Physics, University of Helsinki, Helsinki 00014, Finland., Chou AZ; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China., Bian W; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 101408, China., Dai Z; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 101408, China., Haapanen O; Department of Physics, University of Helsinki, Helsinki 00014, Finland., Enkavi G; Department of Physics, University of Helsinki, Helsinki 00014, Finland., Pollmann C; Department of Biology/Chemistry and Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück 49076, Germany., Vattulainen I; Department of Physics, University of Helsinki, Helsinki 00014, Finland., Cai T; Institute of Quantum Sensing, Institute of Fundamental and Transdisciplinary Research, Zhejiang University, Hangzhou, Zhejiang 310027, China., Piehler J; Department of Biology/Chemistry and Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück 49076, Germany., Chou JJ; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.; State Key Laboratory of Chemical Biology, Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 101408, China.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 May 05; Vol. 123 (18), pp. e2601748123. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.; State Key Laboratory of Chemical Biology, Chinese Academy of Sciences, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Chen+M%22">Chen M</searchLink>; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.<br /><searchLink fieldCode="AU" term="%22Lasram+A%22">Lasram A</searchLink>; Department of Biology/Chemistry and Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück 49076, Germany.<br /><searchLink fieldCode="AU" term="%22Vihuri+S%22">Vihuri S</searchLink>; Department of Physics, University of Helsinki, Helsinki 00014, Finland.<br /><searchLink fieldCode="AU" term="%22Chou+AZ%22">Chou AZ</searchLink>; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.<br /><searchLink fieldCode="AU" term="%22Bian+W%22">Bian W</searchLink>; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 101408, China.<br /><searchLink fieldCode="AU" term="%22Dai+Z%22">Dai Z</searchLink>; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 101408, China.<br /><searchLink fieldCode="AU" term="%22Haapanen+O%22">Haapanen O</searchLink>; Department of Physics, University of Helsinki, Helsinki 00014, Finland.<br /><searchLink fieldCode="AU" term="%22Enkavi+G%22">Enkavi G</searchLink>; Department of Physics, University of Helsinki, Helsinki 00014, Finland.<br /><searchLink fieldCode="AU" term="%22Pollmann+C%22">Pollmann C</searchLink>; Department of Biology/Chemistry and Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück 49076, Germany.<br /><searchLink fieldCode="AU" term="%22Vattulainen+I%22">Vattulainen I</searchLink>; Department of Physics, University of Helsinki, Helsinki 00014, Finland.<br /><searchLink fieldCode="AU" term="%22Cai+T%22">Cai T</searchLink>; Institute of Quantum Sensing, Institute of Fundamental and Transdisciplinary Research, Zhejiang University, Hangzhou, Zhejiang 310027, China.<br /><searchLink fieldCode="AU" term="%22Piehler+J%22">Piehler J</searchLink>; Department of Biology/Chemistry and Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück 49076, Germany.<br /><searchLink fieldCode="AU" term="%22Chou+JJ%22">Chou JJ</searchLink>; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.; State Key Laboratory of Chemical Biology, Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 101408, China.
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              Text: 2026 May 05
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