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Optimal delivery of enteral protein in the critically ill: A systematic review and meta-analysis of randomised controlled trials.

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Title: Optimal delivery of enteral protein in the critically ill: A systematic review and meta-analysis of randomised controlled trials.
Authors: Summers MJ; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia. Electronic address: Matthew.summers@adelaide.edu.au., Bels JLM; Department of Intensive Care Medicine, Maastricht University Medical Centre, Maastricht, the Netherlands; School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands., Karahalios A; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia; Methods and Implementation Support for Clinical and Health (MISCH) Research Hub, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia., Gunaratne RK; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia; Methods and Implementation Support for Clinical and Health (MISCH) Research Hub, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia., Presneill JJ; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia; Department of Critical Care, The University of Melbourne, Melbourne, Australia; Intensive Care Unit, Royal Melbourne Hospital, Parkville, Victoria, Australia., Plummer MP; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; National Health and Medical Research Council of Australia, Centre for Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, South Australia, Australia., Lee ZY; Department of Anaesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany; Department of Cardiac Anaesthesiology and Intensive Care Medicine, Charité, Berlin, Germany., Heyland DK; Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada., Mesotten D; Department of Intensive Care Medicine, Ziekenhuis Oost-Limburg Genk, Belgium; UHasselt, Faculty of Medicine and Life Sciences, Diepenbeek, Belgium., Stoppe C; Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany; Department of Cardiac Anaesthesiology and Intensive Care Medicine, Charité, Berlin, Germany; UTHealth, Center for Outcomes Research and Department of Anaesthesiology, Houston, TX, USA., van de Poll MCG; Department of Intensive Care Medicine, Maastricht University Medical Centre, Maastricht, the Netherlands; School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands; Department of Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands., Peake S; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia; Department of Intensive Care Medicine, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia., Deane AM; Department of Critical Care, The University of Melbourne, Melbourne, Australia; Intensive Care Unit, Royal Melbourne Hospital, Parkville, Victoria, Australia., Chapple LS; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia; National Health and Medical Research Council of Australia, Centre for Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, South Australia, Australia.
Source: Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2026 Jun; Vol. 61, pp. 106665. Date of Electronic Publication: 2026 Apr 16.
Publication Type: Systematic Review; Journal Article; Meta-Analysis
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 8309603 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1983 (Electronic) Linking ISSN: 02615614 NLM ISO Abbreviation: Clin Nutr Subsets: MEDLINE
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  Data: Optimal delivery of enteral protein in the critically ill: A systematic review and meta-analysis of randomised controlled trials.
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  Data: <searchLink fieldCode="AU" term="%22Summers+MJ%22">Summers MJ</searchLink>; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia. Electronic address: Matthew.summers@adelaide.edu.au.<br /><searchLink fieldCode="AU" term="%22Bels+JLM%22">Bels JLM</searchLink>; Department of Intensive Care Medicine, Maastricht University Medical Centre, Maastricht, the Netherlands; School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Karahalios+A%22">Karahalios A</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia; Methods and Implementation Support for Clinical and Health (MISCH) Research Hub, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Gunaratne+RK%22">Gunaratne RK</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia; Methods and Implementation Support for Clinical and Health (MISCH) Research Hub, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Presneill+JJ%22">Presneill JJ</searchLink>; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia; Department of Critical Care, The University of Melbourne, Melbourne, Australia; Intensive Care Unit, Royal Melbourne Hospital, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Plummer+MP%22">Plummer MP</searchLink>; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; National Health and Medical Research Council of Australia, Centre for Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Lee+ZY%22">Lee ZY</searchLink>; Department of Anaesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany; Department of Cardiac Anaesthesiology and Intensive Care Medicine, Charité, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Heyland+DK%22">Heyland DK</searchLink>; Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Mesotten+D%22">Mesotten D</searchLink>; Department of Intensive Care Medicine, Ziekenhuis Oost-Limburg Genk, Belgium; UHasselt, Faculty of Medicine and Life Sciences, Diepenbeek, Belgium.<br /><searchLink fieldCode="AU" term="%22Stoppe+C%22">Stoppe C</searchLink>; Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany; Department of Cardiac Anaesthesiology and Intensive Care Medicine, Charité, Berlin, Germany; UTHealth, Center for Outcomes Research and Department of Anaesthesiology, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22van+de+Poll+MCG%22">van de Poll MCG</searchLink>; Department of Intensive Care Medicine, Maastricht University Medical Centre, Maastricht, the Netherlands; School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands; Department of Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Peake+S%22">Peake S</searchLink>; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia; Department of Intensive Care Medicine, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Deane+AM%22">Deane AM</searchLink>; Department of Critical Care, The University of Melbourne, Melbourne, Australia; Intensive Care Unit, Royal Melbourne Hospital, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Chapple+LS%22">Chapple LS</searchLink>; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia; National Health and Medical Research Council of Australia, Centre for Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, South Australia, Australia.
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