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Nobiletin reprograms cancer cell fate signaling: PI3K/Akt/mTOR-MAPK crosstalk, NF-kB/STAT3 inhibition and chemosensitization.

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Title: Nobiletin reprograms cancer cell fate signaling: PI3K/Akt/mTOR-MAPK crosstalk, NF-kB/STAT3 inhibition and chemosensitization.
Authors: Kamath AJ; Department of Pharmacognosy, Amrita School of Pharmacy, AIMS Health Science campus, Kochi 682 041, India., Syam S; Department of Pharmacognosy, Amrita School of Pharmacy, AIMS Health Science campus, Kochi 682 041, India., Rajesh G; Department of Pharmacognosy, Amrita School of Pharmacy, AIMS Health Science campus, Kochi 682 041, India., Renjini S; Department of Pharmacognosy, Amrita School of Pharmacy, AIMS Health Science campus, Kochi 682 041, India., Vinod BS; Department of Biochemistry, Sree Narayana College, Kollam, India., Raj DBSA; Department of Chemistry, Sree Narayana College, Chempazhanthy, India., Nath LR; Department of Pharmacognosy, Amrita School of Pharmacy, AIMS Health Science campus, Kochi 682 041, India. Electronic address: lekshmirnath@aims.amrita.edu., Sharifi-Rad J; Universidad Espíritu Santo, Samborondón, 092301, Ecuador; Department of Medicine, College of Medicine, Korea University, Seoul 02841, Republic of Korea; Centro de Estudios Tecnológicos y Universitarios del Golfo, Veracruz, Mexico. Electronic address: javadsharifirad@uees.edu.ec., Setzer WN; Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USA; Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA., Calina D; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. Electronic address: daniela.calina@umfcv.ro.
Source: Cellular signalling [Cell Signal] 2026 Aug; Vol. 144, pp. 112549. Date of Electronic Publication: 2026 Apr 26.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Nobiletin reprograms cancer cell fate signaling: PI3K/Akt/mTOR-MAPK crosstalk, NF-kB/STAT3 inhibition and chemosensitization.
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  Data: <searchLink fieldCode="AU" term="%22Kamath+AJ%22">Kamath AJ</searchLink>; Department of Pharmacognosy, Amrita School of Pharmacy, AIMS Health Science campus, Kochi 682 041, India.<br /><searchLink fieldCode="AU" term="%22Syam+S%22">Syam S</searchLink>; Department of Pharmacognosy, Amrita School of Pharmacy, AIMS Health Science campus, Kochi 682 041, India.<br /><searchLink fieldCode="AU" term="%22Rajesh+G%22">Rajesh G</searchLink>; Department of Pharmacognosy, Amrita School of Pharmacy, AIMS Health Science campus, Kochi 682 041, India.<br /><searchLink fieldCode="AU" term="%22Renjini+S%22">Renjini S</searchLink>; Department of Pharmacognosy, Amrita School of Pharmacy, AIMS Health Science campus, Kochi 682 041, India.<br /><searchLink fieldCode="AU" term="%22Vinod+BS%22">Vinod BS</searchLink>; Department of Biochemistry, Sree Narayana College, Kollam, India.<br /><searchLink fieldCode="AU" term="%22Raj+DBSA%22">Raj DBSA</searchLink>; Department of Chemistry, Sree Narayana College, Chempazhanthy, India.<br /><searchLink fieldCode="AU" term="%22Nath+LR%22">Nath LR</searchLink>; Department of Pharmacognosy, Amrita School of Pharmacy, AIMS Health Science campus, Kochi 682 041, India. Electronic address: lekshmirnath@aims.amrita.edu.<br /><searchLink fieldCode="AU" term="%22Sharifi-Rad+J%22">Sharifi-Rad J</searchLink>; Universidad Espíritu Santo, Samborondón, 092301, Ecuador; Department of Medicine, College of Medicine, Korea University, Seoul 02841, Republic of Korea; Centro de Estudios Tecnológicos y Universitarios del Golfo, Veracruz, Mexico. Electronic address: javadsharifirad@uees.edu.ec.<br /><searchLink fieldCode="AU" term="%22Setzer+WN%22">Setzer WN</searchLink>; Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USA; Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA.<br /><searchLink fieldCode="AU" term="%22Calina+D%22">Calina D</searchLink>; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. Electronic address: daniela.calina@umfcv.ro.
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  Data: <searchLink fieldCode="JN" term="%228904683%22">Cellular signalling</searchLink> [Cell Signal] 2026 Aug; Vol. 144, pp. 112549. <i>Date of Electronic Publication: </i>2026 Apr 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8904683 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-3913 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208986568%22">08986568 </searchLink><i>NLM ISO Abbreviation: </i>Cell Signal <i>Subsets: </i>MEDLINE
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              Text: 2026 Aug
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