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Efficacy of the serogroup B Neisseria meningitidis vaccine (4CMenB) in preventing experimental Neisseria gonorrhoeae urethral infection: a double-blind randomised controlled human challenge study protocol.

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Title: Efficacy of the serogroup B Neisseria meningitidis vaccine (4CMenB) in preventing experimental Neisseria gonorrhoeae urethral infection: a double-blind randomised controlled human challenge study protocol.
Authors: Waltmann A; Department of Medicine; Division of Infectious Diseases, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Kronk C; Department of Medicine; Division of Infectious Diseases, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Lapple D; Department of Medicine; Division of Infectious Diseases, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Motley MP; Department of Medicine; Division of Infectious Diseases, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Lin FC; Department of Biostatistics, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Seña AC; Department of Medicine; Division of Infectious Diseases, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Hobbs MM; Department of Medicine; Division of Infectious Diseases, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Duncan JA; Department of Medicine; Division of Infectious Diseases, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA Joseph_Duncan@med.unc.edu.; Department of Pharmacology, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Source: BMJ open [BMJ Open] 2026 Apr 28; Vol. 16 (4), pp. e115296. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy of the serogroup B Neisseria meningitidis vaccine (4CMenB) in preventing experimental Neisseria gonorrhoeae urethral infection: a double-blind randomised controlled human challenge study protocol.
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  Data: <searchLink fieldCode="AU" term="%22Waltmann+A%22">Waltmann A</searchLink>; Department of Medicine; Division of Infectious Diseases, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Kronk+C%22">Kronk C</searchLink>; Department of Medicine; Division of Infectious Diseases, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Lapple+D%22">Lapple D</searchLink>; Department of Medicine; Division of Infectious Diseases, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Motley+MP%22">Motley MP</searchLink>; Department of Medicine; Division of Infectious Diseases, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Lin+FC%22">Lin FC</searchLink>; Department of Biostatistics, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Seña+AC%22">Seña AC</searchLink>; Department of Medicine; Division of Infectious Diseases, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Hobbs+MM%22">Hobbs MM</searchLink>; Department of Medicine; Division of Infectious Diseases, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Duncan+JA%22">Duncan JA</searchLink>; Department of Medicine; Division of Infectious Diseases, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA Joseph_Duncan@med.unc.edu.; Department of Pharmacology, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101552874 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2044-6055 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220446055%22">20446055 </searchLink><i>NLM ISO Abbreviation: </i>BMJ Open <i>Subsets: </i>MEDLINE
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