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DHODH inhibition suppresses cutaneous squamous cell carcinoma growth by the induction of differentiation through perturbation of the cellular redox balance.

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Title: DHODH inhibition suppresses cutaneous squamous cell carcinoma growth by the induction of differentiation through perturbation of the cellular redox balance.
Authors: Khalife F; Univ. Bordeaux, Inserm, BRIC, UMR 1312, Bordeaux, France., Muzotte E; Univ. Bordeaux, Inserm, BRIC, UMR 1312, Bordeaux, France., Naji F; Univ. Bordeaux, Inserm, BRIC, UMR 1312, Bordeaux, France., Mahfouf W; Univ. Bordeaux, Inserm, BRIC, UMR 1312, Bordeaux, France., Izotte J; Animalerie A2, University of Bordeaux, Bordeaux, France., Pinson B; Metabolic Analyses Service, TBMCore-Université de Bordeaux-CNRS UAR 3427-INSERM, US005, Bordeaux, France., Claverol S; Univ. Bordeaux, Bordeaux Proteome, Bordeaux, France., Amoedo N; Inserm U1211 Maladies Rares: Génétique et Métabolisme (MRGM), Université de Bordeaux, Bordeaux, France.; CELLOMET, Centre de Génomique Fonctionnelle de Bordeaux, Université de Bordeaux, Bordeaux, France., Fayyad-Kazan H; Laboratory of Cancer Biology and Molecular Immunology, Faculty of Sciences I, Lebanese University, Hadath, Lebanon., Dousset L; Univ. Bordeaux, Inserm, BRIC, UMR 1312, Bordeaux, France., Rossignol R; Inserm U1211 Maladies Rares: Génétique et Métabolisme (MRGM), Université de Bordeaux, Bordeaux, France.; CELLOMET, Centre de Génomique Fonctionnelle de Bordeaux, Université de Bordeaux, Bordeaux, France., Rezvani HR; Univ. Bordeaux, Inserm, BRIC, UMR 1312, Bordeaux, France. hamid-reza.rezvani@u-bordeaux.fr.
Source: Cell death & disease [Cell Death Dis] 2026 Apr 28; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: DHODH inhibition suppresses cutaneous squamous cell carcinoma growth by the induction of differentiation through perturbation of the cellular redox balance.
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  Data: <searchLink fieldCode="AU" term="%22Khalife+F%22">Khalife F</searchLink>; Univ. Bordeaux, Inserm, BRIC, UMR 1312, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Muzotte+E%22">Muzotte E</searchLink>; Univ. Bordeaux, Inserm, BRIC, UMR 1312, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Naji+F%22">Naji F</searchLink>; Univ. Bordeaux, Inserm, BRIC, UMR 1312, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Mahfouf+W%22">Mahfouf W</searchLink>; Univ. Bordeaux, Inserm, BRIC, UMR 1312, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Izotte+J%22">Izotte J</searchLink>; Animalerie A2, University of Bordeaux, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Pinson+B%22">Pinson B</searchLink>; Metabolic Analyses Service, TBMCore-Université de Bordeaux-CNRS UAR 3427-INSERM, US005, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Claverol+S%22">Claverol S</searchLink>; Univ. Bordeaux, Bordeaux Proteome, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Amoedo+N%22">Amoedo N</searchLink>; Inserm U1211 Maladies Rares: Génétique et Métabolisme (MRGM), Université de Bordeaux, Bordeaux, France.; CELLOMET, Centre de Génomique Fonctionnelle de Bordeaux, Université de Bordeaux, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Fayyad-Kazan+H%22">Fayyad-Kazan H</searchLink>; Laboratory of Cancer Biology and Molecular Immunology, Faculty of Sciences I, Lebanese University, Hadath, Lebanon.<br /><searchLink fieldCode="AU" term="%22Dousset+L%22">Dousset L</searchLink>; Univ. Bordeaux, Inserm, BRIC, UMR 1312, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Rossignol+R%22">Rossignol R</searchLink>; Inserm U1211 Maladies Rares: Génétique et Métabolisme (MRGM), Université de Bordeaux, Bordeaux, France.; CELLOMET, Centre de Génomique Fonctionnelle de Bordeaux, Université de Bordeaux, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Rezvani+HR%22">Rezvani HR</searchLink>; Univ. Bordeaux, Inserm, BRIC, UMR 1312, Bordeaux, France. hamid-reza.rezvani@u-bordeaux.fr.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 Apr 28; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Apr 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE
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              Text: 2026 Apr 28
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