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Associations of social isolation and loneliness with neurological disorders, psychiatric disorders, brain structures and behavioural phenotypes among UK Biobank participants.

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Title: Associations of social isolation and loneliness with neurological disorders, psychiatric disorders, brain structures and behavioural phenotypes among UK Biobank participants.
Authors: Zhao YL; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China., Zhang DD; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China., Gao PY; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China., Fu Y; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China., Ge YJ; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China., Chi HC; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China., Guo ZX; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China., Yu HH; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China., Feng JF; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.; Department of Computer Science, University of Warwick, Coventry, UK., Tan L; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China. dr.tanlan@163.com., Cheng W; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China. wcheng@fudan.edu.cn.; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China. wcheng@fudan.edu.cn.; Department of Computer Science, University of Warwick, Coventry, UK. wcheng@fudan.edu.cn., Zhang YR; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China. yaruzhang@fudan.edu.cn., Yu JT; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China. jintai_yu@fudan.edu.cn.
Source: Nature communications [Nat Commun] 2026 Apr 28; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Zhao+YL%22">Zhao YL</searchLink>; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+DD%22">Zhang DD</searchLink>; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Gao+PY%22">Gao PY</searchLink>; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Fu+Y%22">Fu Y</searchLink>; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Ge+YJ%22">Ge YJ</searchLink>; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Chi+HC%22">Chi HC</searchLink>; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Guo+ZX%22">Guo ZX</searchLink>; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Yu+HH%22">Yu HH</searchLink>; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Feng+JF%22">Feng JF</searchLink>; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.; Department of Computer Science, University of Warwick, Coventry, UK.<br /><searchLink fieldCode="AU" term="%22Tan+L%22">Tan L</searchLink>; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China. dr.tanlan@163.com.<br /><searchLink fieldCode="AU" term="%22Cheng+W%22">Cheng W</searchLink>; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China. wcheng@fudan.edu.cn.; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China. wcheng@fudan.edu.cn.; Department of Computer Science, University of Warwick, Coventry, UK. wcheng@fudan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+YR%22">Zhang YR</searchLink>; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China. yaruzhang@fudan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yu+JT%22">Yu JT</searchLink>; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China. jintai_yu@fudan.edu.cn.
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