Acute dose-dependent effects of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) compared with 3,4-methylenedioxymethamphetamine (MDMA) and psilocybin in a double-blind, placebo-controlled study in healthy participants.
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| Title: | Acute dose-dependent effects of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) compared with 3,4-methylenedioxymethamphetamine (MDMA) and psilocybin in a double-blind, placebo-controlled study in healthy participants. |
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| Authors: | Arikci D; Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Borgulya J; Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Straumann I; Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Vizeli P; Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Luethi D; Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Thomann J; Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Rudin D; Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Vukalovic I; Psychiatric University Hospital, University of Basel, Basel, Switzerland.; Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland., Eckert A; Psychiatric University Hospital, University of Basel, Basel, Switzerland.; Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland., Liechti ME; Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland. matthias.liechti@usb.ch.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. matthias.liechti@usb.ch., Holze F; Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland. friederike.holze@usb.ch.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. friederike.holze@usb.ch. |
| Source: | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2026 Jul; Vol. 51 (8), pp. 1511-1518. Date of Electronic Publication: 2026 Apr 28. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Comparative Study |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42049943 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Acute dose-dependent effects of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) compared with 3,4-methylenedioxymethamphetamine (MDMA) and psilocybin in a double-blind, placebo-controlled study in healthy participants. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Arikci+D%22">Arikci D</searchLink>; Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Borgulya+J%22">Borgulya J</searchLink>; Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Straumann+I%22">Straumann I</searchLink>; Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vizeli+P%22">Vizeli P</searchLink>; Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Luethi+D%22">Luethi D</searchLink>; Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Thomann+J%22">Thomann J</searchLink>; Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rudin+D%22">Rudin D</searchLink>; Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vukalovic+I%22">Vukalovic I</searchLink>; Psychiatric University Hospital, University of Basel, Basel, Switzerland.; Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Eckert+A%22">Eckert A</searchLink>; Psychiatric University Hospital, University of Basel, Basel, Switzerland.; Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Liechti+ME%22">Liechti ME</searchLink>; Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland. matthias.liechti@usb.ch.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. matthias.liechti@usb.ch.<br /><searchLink fieldCode="AU" term="%22Holze+F%22">Holze F</searchLink>; Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland. friederike.holze@usb.ch.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. friederike.holze@usb.ch. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228904907%22">Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology</searchLink> [Neuropsychopharmacology] 2026 Jul; Vol. 51 (8), pp. 1511-1518. <i>Date of Electronic Publication: </i>2026 Apr 28. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Comparative Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8904907 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1740-634X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220893133X%22">0893133X </searchLink><i>NLM ISO Abbreviation: </i>Neuropsychopharmacology <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41386-026-02428-9 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1511 Titles: – TitleFull: Acute dose-dependent effects of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) compared with 3,4-methylenedioxymethamphetamine (MDMA) and psilocybin in a double-blind, placebo-controlled study in healthy participants. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Arikci D – PersonEntity: Name: NameFull: Borgulya J – PersonEntity: Name: NameFull: Straumann I – PersonEntity: Name: NameFull: Vizeli P – PersonEntity: Name: NameFull: Luethi D – PersonEntity: Name: NameFull: Thomann J – PersonEntity: Name: NameFull: Rudin D – PersonEntity: Name: NameFull: Vukalovic I – PersonEntity: Name: NameFull: Eckert A – PersonEntity: Name: NameFull: Liechti ME – PersonEntity: Name: NameFull: Holze F IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2026 Jul Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1740-634X Numbering: – Type: volume Value: 51 – Type: issue Value: 8 Titles: – TitleFull: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Type: main |
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