Excellent outcomes using a novel reduced intensity conditioning with thiotepa and post-transplant cyclophosphamide for HLA-matched related donor transplant in adolescents and adults with sickle cell disease.

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Title: Excellent outcomes using a novel reduced intensity conditioning with thiotepa and post-transplant cyclophosphamide for HLA-matched related donor transplant in adolescents and adults with sickle cell disease.
Authors: Alasbali R; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia., Alzahrani M; Department of Hematology/Oncology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia., Wilkerson K; Department of Medicine, Division of Hematology/Oncology, Vanderbilt-Meharry Center for Excellence in Sickle Cell Disease, Vanderbilt University Medical Center, Nashville, TN, USA., Akhom P; Department of Medicine, Division of Hematology/Oncology, Vanderbilt-Meharry Center for Excellence in Sickle Cell Disease, Vanderbilt University Medical Center, Nashville, TN, USA., Alotaibi F; Department of Research, KFSHRC - Riyadh, Riyadh, Saudi Arabia., Alahmari B; Department of Hematology/Oncology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia., de la Fuente J; Department of Pediatrics, St. Mary's Hospital, Imperial College, London, UK., DeBaun MR; Department of Pediatrics, Vanderbilt-Meharry Sickle Cell Disease Center of Excellence, Vanderbilt University School of Medicine, Nashville, TN, USA., Rasheed W; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia., Samarkandi H; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia.; Pharmaceutical Care Division, KFSHRC, Riyadh, Saudi Arabia., El Fakih R; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia., Saleh M; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia., Elhassan T; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia., Alzahrani H; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia., Aljurf M; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia., Almohareb F; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia., Kassim AA; Department of Medicine, Division of Hematology/Oncology, Vanderbilt-Meharry Center for Excellence in Sickle Cell Disease, Vanderbilt University Medical Center, Nashville, TN, USA., AlAhmari A; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia. aalahmari7@kfshrc.edu.sa.
Source: Bone marrow transplantation [Bone Marrow Transplant] 2026 Jul; Vol. 61 (7), pp. 847-851. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article; Multicenter Study; Clinical Trial
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8702459 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5365 (Electronic) Linking ISSN: 02683369 NLM ISO Abbreviation: Bone Marrow Transplant Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Excellent outcomes using a novel reduced intensity conditioning with thiotepa and post-transplant cyclophosphamide for HLA-matched related donor transplant in adolescents and adults with sickle cell disease.
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  Data: <searchLink fieldCode="AU" term="%22Alasbali+R%22">Alasbali R</searchLink>; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alzahrani+M%22">Alzahrani M</searchLink>; Department of Hematology/Oncology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Wilkerson+K%22">Wilkerson K</searchLink>; Department of Medicine, Division of Hematology/Oncology, Vanderbilt-Meharry Center for Excellence in Sickle Cell Disease, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Akhom+P%22">Akhom P</searchLink>; Department of Medicine, Division of Hematology/Oncology, Vanderbilt-Meharry Center for Excellence in Sickle Cell Disease, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Alotaibi+F%22">Alotaibi F</searchLink>; Department of Research, KFSHRC - Riyadh, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alahmari+B%22">Alahmari B</searchLink>; Department of Hematology/Oncology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22de+la+Fuente+J%22">de la Fuente J</searchLink>; Department of Pediatrics, St. Mary's Hospital, Imperial College, London, UK.<br /><searchLink fieldCode="AU" term="%22DeBaun+MR%22">DeBaun MR</searchLink>; Department of Pediatrics, Vanderbilt-Meharry Sickle Cell Disease Center of Excellence, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Rasheed+W%22">Rasheed W</searchLink>; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Samarkandi+H%22">Samarkandi H</searchLink>; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia.; Pharmaceutical Care Division, KFSHRC, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22El+Fakih+R%22">El Fakih R</searchLink>; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Saleh+M%22">Saleh M</searchLink>; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Elhassan+T%22">Elhassan T</searchLink>; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alzahrani+H%22">Alzahrani H</searchLink>; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Aljurf+M%22">Aljurf M</searchLink>; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Almohareb+F%22">Almohareb F</searchLink>; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Kassim+AA%22">Kassim AA</searchLink>; Department of Medicine, Division of Hematology/Oncology, Vanderbilt-Meharry Center for Excellence in Sickle Cell Disease, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22AlAhmari+A%22">AlAhmari A</searchLink>; Department of Hematology, Stem Cell Transplant & Cellular Therapy, Cancer Centre of Excellence, KFSHRC - Riyadh, Riyadh, Saudi Arabia. aalahmari7@kfshrc.edu.sa.
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  Data: <searchLink fieldCode="JN" term="%228702459%22">Bone marrow transplantation</searchLink> [Bone Marrow Transplant] 2026 Jul; Vol. 61 (7), pp. 847-851. <i>Date of Electronic Publication: </i>2026 Apr 28.
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        Value: 10.1038/s41409-026-02876-3
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