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TMPRSS2-mediated coronavirus spike activation and inhibition.

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Title: TMPRSS2-mediated coronavirus spike activation and inhibition.
Authors: McCallum M; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Case JB; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA., Brown JT; Department of Biochemistry, University of Washington, Seattle, WA, USA., Park YJ; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, Seattle, WA, USA., Lee J; Department of Biochemistry, University of Washington, Seattle, WA, USA., Sutherland E; Department of Chemistry, University of Washington, Seattle, WA, USA., Aggarwal A; The Kirby Institute, The University of New South Wales, Sydney, New South Wales, Australia., Gibson C; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, Seattle, WA, USA., Lempp FA; Vir Biotechnology, San Francisco, CA, USA., Stewart C; Department of Biochemistry, University of Washington, Seattle, WA, USA., Tortorici MA; Department of Biochemistry, University of Washington, Seattle, WA, USA., Sanapala S; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Low JS; Institute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland.; Institute of Microbiology, ETH Zürich, Zurich, Switzerland.; A*STAR Infectious Diseases Labs (A*STAR IDL), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Asarnow D; Department of Biochemistry, University of Washington, Seattle, WA, USA., Bohan D; Vir Biotechnology, San Francisco, CA, USA., Dellota E Jr; Vir Biotechnology, San Francisco, CA, USA., Merz B; Department of Biochemistry, University of Washington, Seattle, WA, USA., Chawla B; Bioqual, Rockville, MD, USA., Kar S; Bioqual, Rockville, MD, USA., Lanzavecchia A; Vir Biotechnology, Bellinzona, Switzerland.; National Institute of Molecular Genetics, Milano, Italy., Sallusto F; Institute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland.; Institute of Microbiology, ETH Zürich, Zurich, Switzerland., Riley NM; Department of Chemistry, University of Washington, Seattle, WA, USA., Turville S; The Kirby Institute, The University of New South Wales, Sydney, New South Wales, Australia., Purcell L; Vir Biotechnology, San Francisco, CA, USA.; Third Rock Ventures, Boston, MA, USA., Diamond MS; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. mdiamond@wustl.edu.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. mdiamond@wustl.edu.; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA. mdiamond@wustl.edu., Veesler D; Department of Biochemistry, University of Washington, Seattle, WA, USA. dveesler@uw.edu.; Howard Hughes Medical Institute, Seattle, WA, USA. dveesler@uw.edu.
Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2026 May; Vol. 33 (5), pp. 810-823. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE
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