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Restraint of Powassan virus replication by TRIM5α facilitates viral avoidance of antiviral immunity.

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Title: Restraint of Powassan virus replication by TRIM5α facilitates viral avoidance of antiviral immunity.
Authors: Broeckel RM; Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.; Current address: Dispatch Biotherapeutics, 25 N 38 St, Philadelphia, PA, USA., Fitzmeyer EA; Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.; Current address: Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA., Chebishev E; Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Shannon JG; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Shue B; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Hage A; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Spada S; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.; Molecular Parasitology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Artikis E; TSE/Prion Biochemistry Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Chiramel AI; Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.; Current address: Boehringer Ingelheim, Birkendorfer Str. 63, Biberach, Germany., McNally KL; Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Larson CL; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., von Kutzleben M; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Robertson SJ; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Offerdahl DK; Biology of Vector-Borne Viruses Section, Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Lakin HA; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Bloom ME; Biology of Vector-Borne Viruses Section, Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Nair V; Reserch Technologies Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Eyre NS; School of Biological Sciences, University of Adelaide, Adelaide, SA, Australia.; Current address: College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Beard MR; School of Biological Sciences, University of Adelaide, Adelaide, SA, Australia., Grigg ME; Molecular Parasitology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Bouamr F; Molecular Parasitology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Best SM; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Mar 16. Date of Electronic Publication: 2026 Mar 16.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Restraint of Powassan virus replication by TRIM5α facilitates viral avoidance of antiviral immunity.
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  Data: <searchLink fieldCode="AU" term="%22Broeckel+RM%22">Broeckel RM</searchLink>; Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.; Current address: Dispatch Biotherapeutics, 25 N 38 St, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Fitzmeyer+EA%22">Fitzmeyer EA</searchLink>; Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.; Current address: Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Chebishev+E%22">Chebishev E</searchLink>; Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.<br /><searchLink fieldCode="AU" term="%22Shannon+JG%22">Shannon JG</searchLink>; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.<br /><searchLink fieldCode="AU" term="%22Shue+B%22">Shue B</searchLink>; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.<br /><searchLink fieldCode="AU" term="%22Hage+A%22">Hage A</searchLink>; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.<br /><searchLink fieldCode="AU" term="%22Spada+S%22">Spada S</searchLink>; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.; Molecular Parasitology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Artikis+E%22">Artikis E</searchLink>; TSE/Prion Biochemistry Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.<br /><searchLink fieldCode="AU" term="%22Chiramel+AI%22">Chiramel AI</searchLink>; Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.; Current address: Boehringer Ingelheim, Birkendorfer Str. 63, Biberach, Germany.<br /><searchLink fieldCode="AU" term="%22McNally+KL%22">McNally KL</searchLink>; Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.<br /><searchLink fieldCode="AU" term="%22Larson+CL%22">Larson CL</searchLink>; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.<br /><searchLink fieldCode="AU" term="%22von+Kutzleben+M%22">von Kutzleben M</searchLink>; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.<br /><searchLink fieldCode="AU" term="%22Robertson+SJ%22">Robertson SJ</searchLink>; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.<br /><searchLink fieldCode="AU" term="%22Offerdahl+DK%22">Offerdahl DK</searchLink>; Biology of Vector-Borne Viruses Section, Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.<br /><searchLink fieldCode="AU" term="%22Lakin+HA%22">Lakin HA</searchLink>; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.<br /><searchLink fieldCode="AU" term="%22Bloom+ME%22">Bloom ME</searchLink>; Biology of Vector-Borne Viruses Section, Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.<br /><searchLink fieldCode="AU" term="%22Nair+V%22">Nair V</searchLink>; Reserch Technologies Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.<br /><searchLink fieldCode="AU" term="%22Eyre+NS%22">Eyre NS</searchLink>; School of Biological Sciences, University of Adelaide, Adelaide, SA, Australia.; Current address: College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Beard+MR%22">Beard MR</searchLink>; School of Biological Sciences, University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Grigg+ME%22">Grigg ME</searchLink>; Molecular Parasitology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Bouamr+F%22">Bouamr F</searchLink>; Molecular Parasitology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Best+SM%22">Best SM</searchLink>; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
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