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Case Report: The role of BRAF mutation in adjuvant and neoadjuvant treatment of melanoma patients: what is the optimal approach?

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Title: Case Report: The role of BRAF mutation in adjuvant and neoadjuvant treatment of melanoma patients: what is the optimal approach?
Authors: Di Pietro FR; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy., Falcone R; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy., Verkhovskaia S; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy., Poti G; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy., Failla CM; Experimental Immunology Laboratory, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy., Carbone ML; Clinical Trial Center, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy., Morelli MF; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy., Zappalà AR; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy., Morese R; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy., Di Rocco ZC; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy., Piesco G; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy., Chesi P; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy., Marchetti P; Scientific Direction, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy., De Galitiis F; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy.
Source: Frontiers in oncology [Front Oncol] 2026 Apr 13; Vol. 16, pp. 1775350. Date of Electronic Publication: 2026 Apr 13 (Print Publication: 2026).
Publication Type: Case Reports; Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Case Report: The role of BRAF mutation in adjuvant and neoadjuvant treatment of melanoma patients: what is the optimal approach?
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  Data: <searchLink fieldCode="AU" term="%22Di+Pietro+FR%22">Di Pietro FR</searchLink>; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Falcone+R%22">Falcone R</searchLink>; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Verkhovskaia+S%22">Verkhovskaia S</searchLink>; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Poti+G%22">Poti G</searchLink>; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Failla+CM%22">Failla CM</searchLink>; Experimental Immunology Laboratory, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Carbone+ML%22">Carbone ML</searchLink>; Clinical Trial Center, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Morelli+MF%22">Morelli MF</searchLink>; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Zappalà+AR%22">Zappalà AR</searchLink>; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Morese+R%22">Morese R</searchLink>; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Rocco+ZC%22">Di Rocco ZC</searchLink>; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Piesco+G%22">Piesco G</searchLink>; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Chesi+P%22">Chesi P</searchLink>; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Marchetti+P%22">Marchetti P</searchLink>; Scientific Direction, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22De+Galitiis+F%22">De Galitiis F</searchLink>; Oncology and Dermato-oncology Department, Rome, Istituto Dermopatico dell'Immacolata (IDI)-Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Rome, Italy.
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