PARP4 ADP-ribosylates PIDD1 to complete a phospho/SUMO/PAR-ylation cascade that orchestrates PIDDosome assembly.
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| Title: | PARP4 ADP-ribosylates PIDD1 to complete a phospho/SUMO/PAR-ylation cascade that orchestrates PIDDosome assembly. |
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| Authors: | Shah RB; Department of Medicine, Division of Hematology and Medical Oncology, Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cell, Developmental and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Li Y; Department of Medicine, Division of Hematology and Medical Oncology, Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cell, Developmental and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Person A; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR, USA., Frigon L; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC, Canada., Ðukić N; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Kini E; Department of Medicine, Division of Hematology and Medical Oncology, Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cell, Developmental and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chen R; Department of Medicine, Division of Hematology and Medical Oncology, Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cell, Developmental and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Pascal JM; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC, Canada., Cohen MS; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR, USA., Ahel I; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Haley JD; Department of Pathology Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA., Sidi S; Department of Medicine, Division of Hematology and Medical Oncology, Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cell, Developmental and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA. |
| Source: | Science advances [Sci Adv] 2026 May; Vol. 12 (18), pp. eadz9284. Date of Electronic Publication: 2026 Apr 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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