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Adeno-associated virus gene therapy-mediated CCR5 blockade suppresses virus replication long term in SHIV-infected macaques.

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Title: Adeno-associated virus gene therapy-mediated CCR5 blockade suppresses virus replication long term in SHIV-infected macaques.
Authors: Wu HL; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Webb GM; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Fuchs SP; Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Pessoa CT; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Hwang JM; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Fisher HK; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., McCullen AJ; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Humkey MC; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Brown MK; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Waytashek CM; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Boyle CD; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Kukula KA; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Potter SK; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Devlin G; Department of Surgery and Department of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Elmore ZC; Department of Surgery and Department of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Hull JA; Department of Surgery and Department of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Zikos J; Nonhuman Primate Reagent Resource, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA., Swanson T; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Armantrout K; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Chun K; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Crank H; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Bailey L; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., White R; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Barber-Axthelm A; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Fischer M; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Smedley JV; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Axthelm MK; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA., Fennessey CM; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Keele BF; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Desrosiers RC; Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Magnani DM; Nonhuman Primate Reagent Resource, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA., Asokan A; Department of Surgery and Department of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Sacha JB; Oregon National Primate Research Center and Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA.
Source: Science translational medicine [Sci Transl Med] 2026 Apr 29; Vol. 18 (847), pp. eadw1976. Date of Electronic Publication: 2026 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Adeno-associated virus gene therapy-mediated CCR5 blockade suppresses virus replication long term in SHIV-infected macaques.
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