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The circadian gene Dec2 promotes pancreatic cancer progression and dormancy through immune evasion.

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Title: The circadian gene Dec2 promotes pancreatic cancer progression and dormancy through immune evasion.
Authors: Wang L; Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Harris CR; Department of Surgery, Division of Surgical Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Dudgeon C; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA., Prela O; Department of Surgery, Division of Surgical Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Cazarin J; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Shih CH; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Davidson C; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Casabianca A; Department of Surgery, Division of Surgical Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., De S; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA., Narrow W; Department of Surgery, Division of Surgical Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Becker J; Dewitt Daughtry Department of Surgery, Division of Surgical Oncology, University of Miami Miller School of Medicine, Miami, FL, USA., Grandgenett PM; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA., Hollingsworth MA; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA., Grem JL; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA., Kim M; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Hong Y; Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI, USA., Gerber S; Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI, USA., Vertino PM; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Gao C; Center for Advanced Research Technologies, University of Rochester Medical Center, Rochester, NY, USA., Klamer Z; Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI, USA., Repesh A; Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI, USA., Hao Y; Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Ryan AT; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Breitenbach M; Department of Surgery, Division of Surgical Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Bianchi A; Dewitt Daughtry Department of Surgery, Division of Surgical Oncology, University of Miami Miller School of Medicine, Miami, FL, USA., Datta J; Dewitt Daughtry Department of Surgery, Division of Surgical Oncology, University of Miami Miller School of Medicine, Miami, FL, USA., Altman BJ; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Haab B; Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI, USA., Carpizo DR; Department of Surgery, Division of Surgical Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: darren_carpizo@urmc.rochester.edu.
Source: Developmental cell [Dev Cell] 2026 Jun 10; Vol. 61 (6), pp. 1208-1222.e9. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1551 (Electronic) Linking ISSN: 15345807 NLM ISO Abbreviation: Dev Cell Subsets: MEDLINE
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  Data: The circadian gene Dec2 promotes pancreatic cancer progression and dormancy through immune evasion.
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  Data: <searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Harris+CR%22">Harris CR</searchLink>; Department of Surgery, Division of Surgical Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Dudgeon+C%22">Dudgeon C</searchLink>; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Prela+O%22">Prela O</searchLink>; Department of Surgery, Division of Surgical Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cazarin+J%22">Cazarin J</searchLink>; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Shih+CH%22">Shih CH</searchLink>; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Davidson+C%22">Davidson C</searchLink>; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Casabianca+A%22">Casabianca A</searchLink>; Department of Surgery, Division of Surgical Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22De+S%22">De S</searchLink>; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Narrow+W%22">Narrow W</searchLink>; Department of Surgery, Division of Surgical Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Becker+J%22">Becker J</searchLink>; Dewitt Daughtry Department of Surgery, Division of Surgical Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Grandgenett+PM%22">Grandgenett PM</searchLink>; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.<br /><searchLink fieldCode="AU" term="%22Hollingsworth+MA%22">Hollingsworth MA</searchLink>; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.<br /><searchLink fieldCode="AU" term="%22Grem+JL%22">Grem JL</searchLink>; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.<br /><searchLink fieldCode="AU" term="%22Kim+M%22">Kim M</searchLink>; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hong+Y%22">Hong Y</searchLink>; Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI, USA.<br /><searchLink fieldCode="AU" term="%22Gerber+S%22">Gerber S</searchLink>; Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI, USA.<br /><searchLink fieldCode="AU" term="%22Vertino+PM%22">Vertino PM</searchLink>; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gao+C%22">Gao C</searchLink>; Center for Advanced Research Technologies, University of Rochester Medical Center, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Klamer+Z%22">Klamer Z</searchLink>; Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI, USA.<br /><searchLink fieldCode="AU" term="%22Repesh+A%22">Repesh A</searchLink>; Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI, USA.<br /><searchLink fieldCode="AU" term="%22Hao+Y%22">Hao Y</searchLink>; Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ryan+AT%22">Ryan AT</searchLink>; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Breitenbach+M%22">Breitenbach M</searchLink>; Department of Surgery, Division of Surgical Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bianchi+A%22">Bianchi A</searchLink>; Dewitt Daughtry Department of Surgery, Division of Surgical Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Datta+J%22">Datta J</searchLink>; Dewitt Daughtry Department of Surgery, Division of Surgical Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Altman+BJ%22">Altman BJ</searchLink>; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Haab+B%22">Haab B</searchLink>; Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI, USA.<br /><searchLink fieldCode="AU" term="%22Carpizo+DR%22">Carpizo DR</searchLink>; Department of Surgery, Division of Surgical Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: darren_carpizo@urmc.rochester.edu.
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