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Genetic activation of ERK2 recapitulates core neurodevelopmental features of Rasopathy syndromes in mice.

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Title: Genetic activation of ERK2 recapitulates core neurodevelopmental features of Rasopathy syndromes in mice.
Authors: Grover KE; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Cappel ZR; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Volz AM; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Cotella EM; Department of Functional and Systems Neuroscience, Instituto Mercedes y Martin Ferreyra INIMEC-CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina., Smallwood K; The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Berryhill CA; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Raje KR; Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Fisher AA; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Casper MCT; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Nardini D; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Rizvi TA; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Salazar RM; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Wooten A; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Williams MT; Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA., Vorhees CV; Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA., Romick LE; Division of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA., Greis KD; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA., Hu YC; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Miles LA; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA., Angus SP; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Ratner N; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA., Prada CE; Edwards Family Division of Genetics and Rare Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Weaver KN; The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Waclaw RR; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Robinson JE; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA. Electronic address: elliott.robinson@cchmc.org.
Source: HGG advances [HGG Adv] 2026 Jul 09; Vol. 7 (3), pp. 100621. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101772885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-2477 (Electronic) Linking ISSN: 26662477 NLM ISO Abbreviation: HGG Adv Subsets: MEDLINE
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  Data: Genetic activation of ERK2 recapitulates core neurodevelopmental features of Rasopathy syndromes in mice.
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  Data: <searchLink fieldCode="AU" term="%22Grover+KE%22">Grover KE</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Cappel+ZR%22">Cappel ZR</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Volz+AM%22">Volz AM</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Cotella+EM%22">Cotella EM</searchLink>; Department of Functional and Systems Neuroscience, Instituto Mercedes y Martin Ferreyra INIMEC-CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina.<br /><searchLink fieldCode="AU" term="%22Smallwood+K%22">Smallwood K</searchLink>; The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Berryhill+CA%22">Berryhill CA</searchLink>; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.<br /><searchLink fieldCode="AU" term="%22Raje+KR%22">Raje KR</searchLink>; Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Fisher+AA%22">Fisher AA</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Casper+MCT%22">Casper MCT</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Nardini+D%22">Nardini D</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Rizvi+TA%22">Rizvi TA</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Salazar+RM%22">Salazar RM</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Wooten+A%22">Wooten A</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Williams+MT%22">Williams MT</searchLink>; Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Vorhees+CV%22">Vorhees CV</searchLink>; Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Romick+LE%22">Romick LE</searchLink>; Division of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Greis+KD%22">Greis KD</searchLink>; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Hu+YC%22">Hu YC</searchLink>; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Miles+LA%22">Miles LA</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Angus+SP%22">Angus SP</searchLink>; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.<br /><searchLink fieldCode="AU" term="%22Ratner+N%22">Ratner N</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Prada+CE%22">Prada CE</searchLink>; Edwards Family Division of Genetics and Rare Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Weaver+KN%22">Weaver KN</searchLink>; The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Waclaw+RR%22">Waclaw RR</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Robinson+JE%22">Robinson JE</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA. Electronic address: elliott.robinson@cchmc.org.
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