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Gilteritinib overcomes second‑generation TKIs resistance in ALK‑rearranged non‑small‑cell lung cancer by inhibiting PD‑L1 and CD8 co‑expression.

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Title: Gilteritinib overcomes second‑generation TKIs resistance in ALK‑rearranged non‑small‑cell lung cancer by inhibiting PD‑L1 and CD8 co‑expression.
Authors: Guo H; Department of Thoracic Surgery, Second Hospital Affiliated to Jilin University, Changchun, Jilin 130000, P.R. China., Li Y; Department of Pharmacy, Jilin Cancer Hospital, Changchun, Jilin 130000, P.R. China., Jin C; Department of Thoracic Surgery, Second Hospital Affiliated to Jilin University, Changchun, Jilin 130000, P.R. China., Qi X; Department of Thoracic Surgery, Second Hospital Affiliated to Jilin University, Changchun, Jilin 130000, P.R. China., Wang J; Department of Thoracic Surgery, Second Hospital Affiliated to Jilin University, Changchun, Jilin 130000, P.R. China., Li B; Department of Thoracic Surgery, Second Hospital Affiliated to Jilin University, Changchun, Jilin 130000, P.R. China., Wang C; Department of Thoracic Surgery, Second Hospital Affiliated to Jilin University, Changchun, Jilin 130000, P.R. China.
Source: International journal of molecular medicine [Int J Mol Med] 2026 Jun; Vol. 57 (6). Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9810955 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-244X (Electronic) Linking ISSN: 11073756 NLM ISO Abbreviation: Int J Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Gilteritinib overcomes second‑generation TKIs resistance in ALK‑rearranged non‑small‑cell lung cancer by inhibiting PD‑L1 and CD8 co‑expression.
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  Data: <searchLink fieldCode="AU" term="%22Guo+H%22">Guo H</searchLink>; Department of Thoracic Surgery, Second Hospital Affiliated to Jilin University, Changchun, Jilin 130000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Pharmacy, Jilin Cancer Hospital, Changchun, Jilin 130000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Jin+C%22">Jin C</searchLink>; Department of Thoracic Surgery, Second Hospital Affiliated to Jilin University, Changchun, Jilin 130000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Qi+X%22">Qi X</searchLink>; Department of Thoracic Surgery, Second Hospital Affiliated to Jilin University, Changchun, Jilin 130000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Thoracic Surgery, Second Hospital Affiliated to Jilin University, Changchun, Jilin 130000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Li+B%22">Li B</searchLink>; Department of Thoracic Surgery, Second Hospital Affiliated to Jilin University, Changchun, Jilin 130000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Department of Thoracic Surgery, Second Hospital Affiliated to Jilin University, Changchun, Jilin 130000, P.R. China.
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  Data: <searchLink fieldCode="JN" term="%229810955%22">International journal of molecular medicine</searchLink> [Int J Mol Med] 2026 Jun; Vol. 57 (6). <i>Date of Electronic Publication: </i>2026 Apr 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22D%2EA%2E+Spandidos%22">D.A. Spandidos </searchLink><i>Country of Publication: </i>Greece <i>NLM ID: </i>9810955 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1791-244X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2211073756%22">11073756 </searchLink><i>NLM ISO Abbreviation: </i>Int J Mol Med <i>Subsets: </i>MEDLINE
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        Value: 10.3892/ijmm.2026.5839
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      – TitleFull: Gilteritinib overcomes second‑generation TKIs resistance in ALK‑rearranged non‑small‑cell lung cancer by inhibiting PD‑L1 and CD8 co‑expression.
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              Text: 2026 Jun
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