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Biotransformation research advances-2025 year in review.

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Title: Biotransformation research advances-2025 year in review.
Authors: Cheruzel L; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA., Argikar UA; Non-clinical Development, Gates Medical Research Institute, Cambridge, MA, USA., Brunetti P; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Chatzopoulou M; UCB, Slough, UK., Chen L; Department of Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai, China., Cho S; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA., Dhaware D; DMPK and Safety Sciences, Orion Pharma, Espoo, Finland., Heck CJS; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Groton, CT, USA., Honrao C; Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics, Merck & Co., Inc., Boston, MA, USA., Khojasteh SC; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA., Lampe JN; Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA., Lang J; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Ma B; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA., Ma S; Department of Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, CA, USA., Rehm K; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Rowley JA; UCB, Slough, UK., Seneviratne HK; Department of Chemistry and Biochemistry, University of Maryland, Baltimore, MD, USA., Seo H; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA., Tang LWT; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Groton, CT, USA., Wang YT; Quantitative, Translational & ADME Sciences (QTAS), AbbVie, North Chicago, IL, USA., Wei C; Quantitative Clinical Pharmacology, Daiichi Sankyo Inc., Basking Ridge, NJ, USA.
Source: Drug metabolism reviews [Drug Metab Rev] 2026 May 25, pp. 1-58. Date of Electronic Publication: 2026 May 25.
Publication Type: Journal Article; Review
Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 0322067 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-9883 (Electronic) Linking ISSN: 03602532 NLM ISO Abbreviation: Drug Metab Rev Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Biotransformation research advances-2025 year in review.
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  Data: <searchLink fieldCode="AU" term="%22Cheruzel+L%22">Cheruzel L</searchLink>; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Argikar+UA%22">Argikar UA</searchLink>; Non-clinical Development, Gates Medical Research Institute, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Brunetti+P%22">Brunetti P</searchLink>; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Chatzopoulou+M%22">Chatzopoulou M</searchLink>; UCB, Slough, UK.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Department of Pharmaceutical Sciences, China Innovation Center of Roche, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Cho+S%22">Cho S</searchLink>; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dhaware+D%22">Dhaware D</searchLink>; DMPK and Safety Sciences, Orion Pharma, Espoo, Finland.<br /><searchLink fieldCode="AU" term="%22Heck+CJS%22">Heck CJS</searchLink>; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Groton, CT, USA.<br /><searchLink fieldCode="AU" term="%22Honrao+C%22">Honrao C</searchLink>; Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics, Merck & Co., Inc., Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Khojasteh+SC%22">Khojasteh SC</searchLink>; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lampe+JN%22">Lampe JN</searchLink>; Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Lang+J%22">Lang J</searchLink>; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ma+B%22">Ma B</searchLink>; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ma+S%22">Ma S</searchLink>; Department of Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rehm+K%22">Rehm K</searchLink>; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rowley+JA%22">Rowley JA</searchLink>; UCB, Slough, UK.<br /><searchLink fieldCode="AU" term="%22Seneviratne+HK%22">Seneviratne HK</searchLink>; Department of Chemistry and Biochemistry, University of Maryland, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Seo+H%22">Seo H</searchLink>; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tang+LWT%22">Tang LWT</searchLink>; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Groton, CT, USA.<br /><searchLink fieldCode="AU" term="%22Wang+YT%22">Wang YT</searchLink>; Quantitative, Translational & ADME Sciences (QTAS), AbbVie, North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Wei+C%22">Wei C</searchLink>; Quantitative Clinical Pharmacology, Daiichi Sankyo Inc., Basking Ridge, NJ, USA.
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  Data: <searchLink fieldCode="JN" term="%220322067%22">Drug metabolism reviews</searchLink> [Drug Metab Rev] 2026 May 25, pp. 1-58. <i>Date of Electronic Publication: </i>2026 May 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Informa+Healthcare%22">Informa Healthcare </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0322067 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-9883 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203602532%22">03602532 </searchLink><i>NLM ISO Abbreviation: </i>Drug Metab Rev <i>Subsets: </i>MEDLINE
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