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Atomoxetine attenuates methotrexate-induced lung injury in rats implicating TLR4/NF-κB and Bax/Bcl-2/caspase-3 signaling cascades: a study based on molecular docking and experimental validation.

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Title: Atomoxetine attenuates methotrexate-induced lung injury in rats implicating TLR4/NF-κB and Bax/Bcl-2/caspase-3 signaling cascades: a study based on molecular docking and experimental validation.
Authors: Mohyeldin RH; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, 61111, Minia, Egypt., Sharata EE; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, 61111, Minia, Egypt., Ibrahim AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, 61111, Minia, Egypt., Attya ME; Department of Pathology, Faculty of Medicine, Minia University, Minia, 61519, Egypt.; Department of Pathology, Faculty of Medicine, Minia National University, Minia, 61519, Egypt., Kotb ASM; Department of Biochemistry, Molecular Biology and Physiology, Faculty of Medicine, Mutah University, Al‑Karak, Jordan.; Medical Physiology Department, Faculty of Medicine, Minia University, Minia, 61519, Egypt., Rofaeil RR; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, 61111, Minia, Egypt.; Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minia, 61511, Egypt., Khalifa YMMA; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, 61111, Minia, Egypt., Abdelnaser M; Department of Biochemistry, Faculty of Pharmacy, Deraya University, 61111, Minia, Egypt. mahmoud.abdelnaser@deraya.edu.eg.
Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Jul; Vol. 399 (10), pp. 15609-15627. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
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  Data: Atomoxetine attenuates methotrexate-induced lung injury in rats implicating TLR4/NF-κB and Bax/Bcl-2/caspase-3 signaling cascades: a study based on molecular docking and experimental validation.
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  Data: <searchLink fieldCode="AU" term="%22Mohyeldin+RH%22">Mohyeldin RH</searchLink>; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, 61111, Minia, Egypt.<br /><searchLink fieldCode="AU" term="%22Sharata+EE%22">Sharata EE</searchLink>; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, 61111, Minia, Egypt.<br /><searchLink fieldCode="AU" term="%22Ibrahim+AM%22">Ibrahim AM</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, 61111, Minia, Egypt.<br /><searchLink fieldCode="AU" term="%22Attya+ME%22">Attya ME</searchLink>; Department of Pathology, Faculty of Medicine, Minia University, Minia, 61519, Egypt.; Department of Pathology, Faculty of Medicine, Minia National University, Minia, 61519, Egypt.<br /><searchLink fieldCode="AU" term="%22Kotb+ASM%22">Kotb ASM</searchLink>; Department of Biochemistry, Molecular Biology and Physiology, Faculty of Medicine, Mutah University, Al‑Karak, Jordan.; Medical Physiology Department, Faculty of Medicine, Minia University, Minia, 61519, Egypt.<br /><searchLink fieldCode="AU" term="%22Rofaeil+RR%22">Rofaeil RR</searchLink>; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, 61111, Minia, Egypt.; Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minia, 61511, Egypt.<br /><searchLink fieldCode="AU" term="%22Khalifa+YMMA%22">Khalifa YMMA</searchLink>; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, 61111, Minia, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdelnaser+M%22">Abdelnaser M</searchLink>; Department of Biochemistry, Faculty of Pharmacy, Deraya University, 61111, Minia, Egypt. mahmoud.abdelnaser@deraya.edu.eg.
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  Data: <searchLink fieldCode="JN" term="%220326264%22">Naunyn-Schmiedeberg's archives of pharmacology</searchLink> [Naunyn Schmiedebergs Arch Pharmacol] 2026 Jul; Vol. 399 (10), pp. 15609-15627. <i>Date of Electronic Publication: </i>2026 Apr 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0326264 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-1912 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200281298%22">00281298 </searchLink><i>NLM ISO Abbreviation: </i>Naunyn Schmiedebergs Arch Pharmacol <i>Subsets: </i>MEDLINE
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      – TitleFull: Atomoxetine attenuates methotrexate-induced lung injury in rats implicating TLR4/NF-κB and Bax/Bcl-2/caspase-3 signaling cascades: a study based on molecular docking and experimental validation.
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              Text: 2026 Jul
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