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Discovery and Evaluation of 6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline Derivatives as P-gp Inhibitors to Overcome Multidrug Resistance in Eca109/VCR Cells.

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Title: Discovery and Evaluation of 6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline Derivatives as P-gp Inhibitors to Overcome Multidrug Resistance in Eca109/VCR Cells.
Authors: Lai WJ; College of Chemistry and Environmental Engineering, Sichuan University of Science and Engineering, Zigong, China.; Department of Medicinal Chemistry, Third Military Medical University, Chongqing, China., Guo CL; College of Chemistry and Environmental Engineering, Sichuan University of Science and Engineering, Zigong, China.; Department of Medicinal Chemistry, Third Military Medical University, Chongqing, China., Xia JY; College of Chemistry and Environmental Engineering, Sichuan University of Science and Engineering, Zigong, China.; Department of Medicinal Chemistry, Third Military Medical University, Chongqing, China., Cao WX; Department of Medicinal Chemistry, Third Military Medical University, Chongqing, China., Li HW; Department of Medicinal Chemistry, Third Military Medical University, Chongqing, China., Yu T; Department of Medicinal Chemistry, Third Military Medical University, Chongqing, China., Tian L; College of Chemistry and Environmental Engineering, Sichuan University of Science and Engineering, Zigong, China.; Department of Medicinal Chemistry, Third Military Medical University, Chongqing, China., Xie Y; College of Chemistry and Environmental Engineering, Sichuan University of Science and Engineering, Zigong, China., Li Y; College of Chemistry and Environmental Engineering, Sichuan University of Science and Engineering, Zigong, China., Zeng R; Department of Medicinal Chemistry, Third Military Medical University, Chongqing, China., Ouyang Q; Department of Medicinal Chemistry, Third Military Medical University, Chongqing, China.
Source: ChemMedChem [ChemMedChem] 2026 May 14; Vol. 21 (9), pp. e202501112.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE
Database: MEDLINE Ultimate
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              Text: 2026 May 14
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