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Targeted Intra-Atrial Delivery of GMP-Grade Human Extracellular Vesicles Prevents Inflammation-Driven Postoperative Atrial Fibrillation in Pigs.

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Title: Targeted Intra-Atrial Delivery of GMP-Grade Human Extracellular Vesicles Prevents Inflammation-Driven Postoperative Atrial Fibrillation in Pigs.
Authors: Ahmed N; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada; Rhythm Biotherapeutics Inc, Ottawa, Ontario, Canada., Parent S; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada., René CA; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Rhythm Biotherapeutics Inc, Ottawa, Ontario, Canada., Kovacina N; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada., St Amant J; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada., Napoleone M; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada., Collet B; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada., Kahn S; Division of Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Courtman D; Division of Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Stewart DJ; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada; Division of Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Chan V; Division of Cardiac Surgery, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada., Davis DR; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada; Rhythm Biotherapeutics Inc, Ottawa, Ontario, Canada. Electronic address: ddavis@ottawaheart.ca.
Source: JACC. Basic to translational science [JACC Basic Transl Sci] 2026 Jun; Vol. 11 (6), pp. 101555. Date of Electronic Publication: 2026 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeted Intra-Atrial Delivery of GMP-Grade Human Extracellular Vesicles Prevents Inflammation-Driven Postoperative Atrial Fibrillation in Pigs.
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  Data: <searchLink fieldCode="AU" term="%22Ahmed+N%22">Ahmed N</searchLink>; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada; Rhythm Biotherapeutics Inc, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Parent+S%22">Parent S</searchLink>; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22René+CA%22">René CA</searchLink>; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Rhythm Biotherapeutics Inc, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Kovacina+N%22">Kovacina N</searchLink>; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22St+Amant+J%22">St Amant J</searchLink>; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Napoleone+M%22">Napoleone M</searchLink>; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Collet+B%22">Collet B</searchLink>; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Kahn+S%22">Kahn S</searchLink>; Division of Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Courtman+D%22">Courtman D</searchLink>; Division of Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Stewart+DJ%22">Stewart DJ</searchLink>; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada; Division of Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Chan+V%22">Chan V</searchLink>; Division of Cardiac Surgery, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Davis+DR%22">Davis DR</searchLink>; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada; Rhythm Biotherapeutics Inc, Ottawa, Ontario, Canada. Electronic address: ddavis@ottawaheart.ca.
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  Data: <searchLink fieldCode="JN" term="%22101677259%22">JACC. Basic to translational science</searchLink> [JACC Basic Transl Sci] 2026 Jun; Vol. 11 (6), pp. 101555. <i>Date of Electronic Publication: </i>2026 Apr 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+on+behalf+of+the+American+College+of+Cardiology+Foundation%22">Elsevier on behalf of the American College of Cardiology Foundation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101677259 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2452-302X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222452302X%22">2452302X </searchLink><i>NLM ISO Abbreviation: </i>JACC Basic Transl Sci <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2026 Jun
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