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CDK4/6 inhibitors plus endocrine therapy versus endocrine monotherapy in hormone receptor-positive, HER2-negative advanced breast cancer: a reconstructed individual patient data meta-analysis of phase 3 randomised controlled trials.

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Title: CDK4/6 inhibitors plus endocrine therapy versus endocrine monotherapy in hormone receptor-positive, HER2-negative advanced breast cancer: a reconstructed individual patient data meta-analysis of phase 3 randomised controlled trials.
Authors: Beshr MS; Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen., Fahaid A; Faculty of Medicine, University of Tripoli, Tripoli, Libya., Shembesh RH; Faculty of Medicine, Libyan International Medical University, Benghazi, Libya., Valachis A; Department of Oncology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Lambertini M; Department of Internal Medicine and Medical Specialties, School of Medicine, University of Genova, Genoa, Italy; Department of Medical Oncology, UO Clinical Di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Cortesi L; Medical Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy; Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy., Alesawy AF; Clinical Microbiology and Immunology Department, Benha University, Qalubiya, Egypt., Abraheem A; Faculty of medicine, University of Al-azhar, Cairo, Egypt., Alsharedi M; Markey Cancer Center, UK HealthCare, University of Kentucky, KY, USA., Ali ME; Internal Medicine Department, Crestwood Medical Center, Huntsville, AL, USA., Elkhanany A; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA., Azim HA Jr; Cairo Cure Oncology Centre, Cairo, Egypt., Velikova G; Leeds Institute of Medical Research, University of Leeds, St James's University Hospital, Leeds, UK; Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, UK., Elhadi M; College of Medicine, Korea University, Seoul, South Korea. Electronic address: muhammed-elhadi@korea.ac.kr.
Source: The Lancet. Oncology [Lancet Oncol] 2026 May; Vol. 27 (5), pp. 592-603.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 100957246 Publication Model: Print Cited Medium: Internet ISSN: 1474-5488 (Electronic) Linking ISSN: 14702045 NLM ISO Abbreviation: Lancet Oncol Subsets: MEDLINE
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  Data: CDK4/6 inhibitors plus endocrine therapy versus endocrine monotherapy in hormone receptor-positive, HER2-negative advanced breast cancer: a reconstructed individual patient data meta-analysis of phase 3 randomised controlled trials.
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  Data: <searchLink fieldCode="AU" term="%22Beshr+MS%22">Beshr MS</searchLink>; Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.<br /><searchLink fieldCode="AU" term="%22Fahaid+A%22">Fahaid A</searchLink>; Faculty of Medicine, University of Tripoli, Tripoli, Libya.<br /><searchLink fieldCode="AU" term="%22Shembesh+RH%22">Shembesh RH</searchLink>; Faculty of Medicine, Libyan International Medical University, Benghazi, Libya.<br /><searchLink fieldCode="AU" term="%22Valachis+A%22">Valachis A</searchLink>; Department of Oncology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.<br /><searchLink fieldCode="AU" term="%22Lambertini+M%22">Lambertini M</searchLink>; Department of Internal Medicine and Medical Specialties, School of Medicine, University of Genova, Genoa, Italy; Department of Medical Oncology, UO Clinical Di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Cortesi+L%22">Cortesi L</searchLink>; Medical Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy; Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Alesawy+AF%22">Alesawy AF</searchLink>; Clinical Microbiology and Immunology Department, Benha University, Qalubiya, Egypt.<br /><searchLink fieldCode="AU" term="%22Abraheem+A%22">Abraheem A</searchLink>; Faculty of medicine, University of Al-azhar, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Alsharedi+M%22">Alsharedi M</searchLink>; Markey Cancer Center, UK HealthCare, University of Kentucky, KY, USA.<br /><searchLink fieldCode="AU" term="%22Ali+ME%22">Ali ME</searchLink>; Internal Medicine Department, Crestwood Medical Center, Huntsville, AL, USA.<br /><searchLink fieldCode="AU" term="%22Elkhanany+A%22">Elkhanany A</searchLink>; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Azim+HA+Jr%22">Azim HA Jr</searchLink>; Cairo Cure Oncology Centre, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Velikova+G%22">Velikova G</searchLink>; Leeds Institute of Medical Research, University of Leeds, St James's University Hospital, Leeds, UK; Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Elhadi+M%22">Elhadi M</searchLink>; College of Medicine, Korea University, Seoul, South Korea. Electronic address: muhammed-elhadi@korea.ac.kr.
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  Data: <searchLink fieldCode="JN" term="%22100957246%22">The Lancet. Oncology</searchLink> [Lancet Oncol] 2026 May; Vol. 27 (5), pp. 592-603.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lancet+Pub%2E+Group%22">Lancet Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100957246 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-5488 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214702045%22">14702045 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Oncol <i>Subsets: </i>MEDLINE
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              Text: 2026 May
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