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Clinical features, genetics, treatment, and long-term outcomes of STAT3 hyper-IgE syndrome: Single-center cohort analysis.

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Title: Clinical features, genetics, treatment, and long-term outcomes of STAT3 hyper-IgE syndrome: Single-center cohort analysis.
Authors: Freeman AF; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md. Electronic address: freemaal@mail.nih.gov., Wang C; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md., Urban A; Clinical Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Md., Martin I; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md., Dang L; Biostatistics Research Branch, NIAID, NIH, Bethesda, Md., Davis J; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md., Bergerson JRE; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md., Ali S; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md., An ZA; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md., Patel M; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md., Williamson H; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md., Marciano BE; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md., Lafeer C; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md., Roy S; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md., Ulrick J; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md., Heller T; Translational Hepatology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, Md., Sharma D; Digestive Diseases Branch, NIDDK, Bethesda, Md., Castelo-Soccio L; Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Bethesda, Md., Cowen EW; Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Bethesda, Md., Kong HH; Cutaneous Microbiome and Inflammation Section, Dermatology Branch, NIAMS, NIH, Bethesda, Md., Gupta S; Lupus Clinical Trials Unit, NIAMS, NIH, Bethesda, Md., Ghosh R; Centralized Sequencing Program, NIAID, NIH, Bethesda, Md., Seifert BA; Centralized Sequencing Program, NIAID, NIH, Bethesda, Md., Tokita MJ; Centralized Sequencing Program, NIAID, NIH, Bethesda, Md., Walkiewicz MA; Centralized Sequencing Program, NIAID, NIH, Bethesda, Md., Similuk M; Centralized Sequencing Program, NIAID, NIH, Bethesda, Md., Stoddard J; Immunology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Md., Rosenzweig SD; Immunology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Md., Matta JR; Biomedical and Metabolic Imaging Branch, NIDDK, NIH, Bethesda, Md., Gharib AM; Biomedical and Metabolic Imaging Branch, NIDDK, NIH, Bethesda, Md., Jahanmir G; Dental Clinic, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Md., Brenchley L; Dental Clinic, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Md; Laboratory of Host Immunity and Microbiome, NIAID, NIH, Bethesda, Md., Shastri K; Dental Clinic, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Md., Moutsopoulos NM; Laboratory of Host Immunity and Microbiome, NIAID, NIH, Bethesda, Md., Kitani T; National Institute of Neurologic Disorders and Stroke, NIH, Bethesda, Md., Arnold DE; Immune Deficiency Cellular Therapy Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Md., Dimitrova D; Center for Immuno-Oncology, National Cancer Institute, NIH, Bethesda, Md., Gonzalez CE; Immune Deficiency Cellular Therapy Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Md., Pai SY; Immune Deficiency Cellular Therapy Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Md., Malech HL; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md., Gallin JI; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md., Fennelly K; Laboratory of Chronic Airway Infection, National Heart, Lung, and Blood Institute, NIH, Bethesda, Md., Olivier KN; Division of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, University of North Carolina, Chapel Hill, NC., Mackie J; Garvan Institute of Medical Research, Darlinghurst, Australia; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales Sydney, Sydney, Australia., Tangye SG; Garvan Institute of Medical Research, Darlinghurst, Australia; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales Sydney, Sydney, Australia., Hsu AP; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md., Milner JD; Division of Pediatric Allergy, Immunology and Rheumatology, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY., Heimall J; Division of Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, Pa., Holland SM; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md.
Source: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2026 Apr 28. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Mosby Country of Publication: United States NLM ID: 1275002 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6825 (Electronic) Linking ISSN: 00916749 NLM ISO Abbreviation: J Allergy Clin Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Clinical features, genetics, treatment, and long-term outcomes of STAT3 hyper-IgE syndrome: Single-center cohort analysis.
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  Data: <searchLink fieldCode="AU" term="%22Freeman+AF%22">Freeman AF</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md. 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