Multicenter study of bleeding and thromboembolic events with durvalumab tremelimumab vs. atezolizumab and bevacizumab in advanced HCC.

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Title: Multicenter study of bleeding and thromboembolic events with durvalumab tremelimumab vs. atezolizumab and bevacizumab in advanced HCC.
Authors: Ben Khaled N; Department of Medicine II, University Hospital, LMU Munich, Munich, Germany(†)(,)(‡)., Mohr R; Department of Hepatology and Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin, Germany(†)., Jochheim LS; Department of Gastroenterology, Hepatology and Transplant Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; Department of Nuclear Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Zarka V; Division of Hepatology, Department of Medicine II, University Hospital Würzburg, Würzburg, Germany(†)(,)(‡)., Karin M; Department of Medicine II, University Hospital, LMU Munich, Munich, Germany(†)(,)(‡)., Artusa F; Department of Hepatology and Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin, Germany(†)., Schütte JM; Department of Gastroenterology, Hepatology and Transplant Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Himmelsbach V; Department of Gastroenterology, Hepatology and Endocrinology, University Hospital Frankfurt, Frankfurt/Main, Germany(†)., Ehmer U; TUM School of Medicine and Health, Department for Internal Medicine II, TUM University Hospital, Technical University of Munich, Munich, Germany (†)(,)(‡)., Böttcher K; TUM School of Medicine and Health, Department for Internal Medicine II, TUM University Hospital, Technical University of Munich, Munich, Germany (†)(,)(‡); Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany(†); M3 Research Center, University Hospital Tübingen, University of Tübingen, Tübingen, Germany(†)., Foerster F; Department of Medicine I, University Medical Center of the Johannes-Gutenberg University Mainz, Germany(†)., Gairing SJ; Department of Medicine I, University Medical Center of the Johannes-Gutenberg University Mainz, Germany(†)., Bark P; Department of Medicine I, University Medical Center of the Johannes-Gutenberg University Mainz, Germany(†)., Weich A; Division of Gastroenterology, Department of Medicine II, University Hospital Würzburg, Würzburg, Germany(‡)., Piseddu I; Department of Medicine II, University Hospital, LMU Munich, Munich, Germany(†)(,)(‡)., Rau M; Division of Hepatology, Department of Medicine II, University Hospital Würzburg, Würzburg, Germany(†)(,)(‡)., Scheiner B; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria(†)., Balcar L; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria(†)., Venerito M; Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital Magdeburg, Magdeburg, Germany., Heumann P; Gastroenterology, Hepatology, Endocrinology, Rheumatology and Infectious Diseases, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany(‡)., Kandulski A; Gastroenterology, Hepatology, Endocrinology, Rheumatology and Infectious Diseases, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany(‡)., Leyh C; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Düsseldorf, Germany(†)., Roderburg C; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Düsseldorf, Germany(†)., Lüdde T; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Düsseldorf, Germany(†)., Pinter M; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria(†)., Mayerle J; Department of Medicine II, University Hospital, LMU Munich, Munich, Germany(†)(,)(‡)., Marquardt JU; Department of Medicine I, University Medical Center, Lübeck, Germany(†)., Finkelmeier F; Department of Gastroenterology, Hepatology and Endocrinology, University Hospital Frankfurt, Frankfurt/Main, Germany(†)., De Toni EN; Department of Medicine II, University Hospital, LMU Munich, Munich, Germany(†)(,)(‡)., Geier A; Division of Hepatology, Department of Medicine II, University Hospital Würzburg, Würzburg, Germany(†)(,)(‡)., Reiter FP; Division of Hepatology, Department of Medicine II, University Hospital Würzburg, Würzburg, Germany(†)(,)(‡). Electronic address: Reiter_F@ukw.de.
Source: JHEP reports : innovation in hepatology [JHEP Rep] 2026 Jun; Vol. 8 (6), pp. 101818. Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article; Multicenter Study; Comparative Study
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101761237 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-5559 (Electronic) Linking ISSN: 25895559 NLM ISO Abbreviation: JHEP Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Multicenter study of bleeding and thromboembolic events with durvalumab tremelimumab vs. atezolizumab and bevacizumab in advanced HCC.
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  Data: <searchLink fieldCode="AU" term="%22Ben+Khaled+N%22">Ben Khaled N</searchLink>; Department of Medicine II, University Hospital, LMU Munich, Munich, Germany(†)(,)(‡).<br /><searchLink fieldCode="AU" term="%22Mohr+R%22">Mohr R</searchLink>; Department of Hepatology and Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin, Germany(†).<br /><searchLink fieldCode="AU" term="%22Jochheim+LS%22">Jochheim LS</searchLink>; Department of Gastroenterology, Hepatology and Transplant Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; Department of Nuclear Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Zarka+V%22">Zarka V</searchLink>; Division of Hepatology, Department of Medicine II, University Hospital Würzburg, Würzburg, Germany(†)(,)(‡).<br /><searchLink fieldCode="AU" term="%22Karin+M%22">Karin M</searchLink>; Department of Medicine II, University Hospital, LMU Munich, Munich, Germany(†)(,)(‡).<br /><searchLink fieldCode="AU" term="%22Artusa+F%22">Artusa F</searchLink>; Department of Hepatology and Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin, Germany(†).<br /><searchLink fieldCode="AU" term="%22Schütte+JM%22">Schütte JM</searchLink>; Department of Gastroenterology, Hepatology and Transplant Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Himmelsbach+V%22">Himmelsbach V</searchLink>; Department of Gastroenterology, Hepatology and Endocrinology, University Hospital Frankfurt, Frankfurt/Main, Germany(†).<br /><searchLink fieldCode="AU" term="%22Ehmer+U%22">Ehmer U</searchLink>; TUM School of Medicine and Health, Department for Internal Medicine II, TUM University Hospital, Technical University of Munich, Munich, Germany (†)(,)(‡).<br /><searchLink fieldCode="AU" term="%22Böttcher+K%22">Böttcher K</searchLink>; TUM School of Medicine and Health, Department for Internal Medicine II, TUM University Hospital, Technical University of Munich, Munich, Germany (†)(,)(‡); Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany(†); M3 Research Center, University Hospital Tübingen, University of Tübingen, Tübingen, Germany(†).<br /><searchLink fieldCode="AU" term="%22Foerster+F%22">Foerster F</searchLink>; Department of Medicine I, University Medical Center of the Johannes-Gutenberg University Mainz, Germany(†).<br /><searchLink fieldCode="AU" term="%22Gairing+SJ%22">Gairing SJ</searchLink>; Department of Medicine I, University Medical Center of the Johannes-Gutenberg University Mainz, Germany(†).<br /><searchLink fieldCode="AU" term="%22Bark+P%22">Bark P</searchLink>; Department of Medicine I, University Medical Center of the Johannes-Gutenberg University Mainz, Germany(†).<br /><searchLink fieldCode="AU" term="%22Weich+A%22">Weich A</searchLink>; Division of Gastroenterology, Department of Medicine II, University Hospital Würzburg, Würzburg, Germany(‡).<br /><searchLink fieldCode="AU" term="%22Piseddu+I%22">Piseddu I</searchLink>; Department of Medicine II, University Hospital, LMU Munich, Munich, Germany(†)(,)(‡).<br /><searchLink fieldCode="AU" term="%22Rau+M%22">Rau M</searchLink>; Division of Hepatology, Department of Medicine II, University Hospital Würzburg, Würzburg, Germany(†)(,)(‡).<br /><searchLink fieldCode="AU" term="%22Scheiner+B%22">Scheiner B</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria(†).<br /><searchLink fieldCode="AU" term="%22Balcar+L%22">Balcar L</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria(†).<br /><searchLink fieldCode="AU" term="%22Venerito+M%22">Venerito M</searchLink>; Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital Magdeburg, Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Heumann+P%22">Heumann P</searchLink>; Gastroenterology, Hepatology, Endocrinology, Rheumatology and Infectious Diseases, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany(‡).<br /><searchLink fieldCode="AU" term="%22Kandulski+A%22">Kandulski A</searchLink>; Gastroenterology, Hepatology, Endocrinology, Rheumatology and Infectious Diseases, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany(‡).<br /><searchLink fieldCode="AU" term="%22Leyh+C%22">Leyh C</searchLink>; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Düsseldorf, Germany(†).<br /><searchLink fieldCode="AU" term="%22Roderburg+C%22">Roderburg C</searchLink>; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Düsseldorf, Germany(†).<br /><searchLink fieldCode="AU" term="%22Lüdde+T%22">Lüdde T</searchLink>; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Düsseldorf, Germany(†).<br /><searchLink fieldCode="AU" term="%22Pinter+M%22">Pinter M</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria(†).<br /><searchLink fieldCode="AU" term="%22Mayerle+J%22">Mayerle J</searchLink>; Department of Medicine II, University Hospital, LMU Munich, Munich, Germany(†)(,)(‡).<br /><searchLink fieldCode="AU" term="%22Marquardt+JU%22">Marquardt JU</searchLink>; Department of Medicine I, University Medical Center, Lübeck, Germany(†).<br /><searchLink fieldCode="AU" term="%22Finkelmeier+F%22">Finkelmeier F</searchLink>; Department of Gastroenterology, Hepatology and Endocrinology, University Hospital Frankfurt, Frankfurt/Main, Germany(†).<br /><searchLink fieldCode="AU" term="%22De+Toni+EN%22">De Toni EN</searchLink>; Department of Medicine II, University Hospital, LMU Munich, Munich, Germany(†)(,)(‡).<br /><searchLink fieldCode="AU" term="%22Geier+A%22">Geier A</searchLink>; Division of Hepatology, Department of Medicine II, University Hospital Würzburg, Würzburg, Germany(†)(,)(‡).<br /><searchLink fieldCode="AU" term="%22Reiter+FP%22">Reiter FP</searchLink>; Division of Hepatology, Department of Medicine II, University Hospital Würzburg, Würzburg, Germany(†)(,)(‡). Electronic address: Reiter_F@ukw.de.
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