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Systematic review and meta-analysis of stroke blood biomarker data highlights need for more translational research methods.

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Title: Systematic review and meta-analysis of stroke blood biomarker data highlights need for more translational research methods.
Authors: Smothers CG; School of Nursing, Case Western Reserve University, Cleveland, OH, USA., Gandhi SA; School of Medicine, Case Western Reserve University, Cleveland, OH, USA., Chang JH; Department of Orthopedics, Sutter Health, Santa Barbara, CA, USA., Tahir SM; Department of Dermatology and Plastic Surgery, Cleveland Clinic, Cleveland, OH, USA., Kelley J; Department of Internal Medicine, Stamford Hospital, Stamford, CT, USA., Wang E; Department of Neurology, Rush University, Chicago, IL, USA., Fareed K; School of Medicine, Stanford University, Palo Alto, CA, USA., Mack H; College of Public Health, Ohio State University, Columbus, OH, USA., Dong C; Division of Clinical Research Services, Nationwide Children's Hospital, Columbus, OH, USA., Witort M; College of Arts and Sciences, Case Western Reserve University, Cleveland, OH, USA., Armentrout BL; School of Nursing, Case Western Reserve University, Cleveland, OH, USA., Crawford D; School of Science, Technology, and Engineering, Dillard University, New Orleans, LA, USA., Wang J; Molecular Biomarker Core, Case Western Reserve University, Cleveland, OH, USA., Williams K; Molecular Biomarker Core, Case Western Reserve University, Cleveland, OH, USA., Bud Z; School of Nursing, Case Western Reserve University, Cleveland, OH, USA., Horvat-Davey C; School of Nursing, Case Western Reserve University, Cleveland, OH, USA., Winkelman C; School of Nursing, Case Western Reserve University, Cleveland, OH, USA., Martha SR; College of Nursing, University of Illinois at Chicago, Chicago, IL, USA., Schrock JW; School of Medicine, Case Western Reserve University, Cleveland, OH, USA.; Department of Emergency Medicine, MetroHealth Medical Center, Cleveland, OH, USA., Ardelt AA; School of Medicine, Case Western Reserve University, Cleveland, OH, USA.; Department of Neurology, MetroHealth Medical Center, Cleveland, OH, USA., O'Connell GC; School of Nursing, Case Western Reserve University, Cleveland, OH, USA. grant.oconnell@case.edu.; Molecular Biomarker Core, Case Western Reserve University, Cleveland, OH, USA. grant.oconnell@case.edu.
Source: Nature communications [Nat Commun] 2026 Apr 30; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article; Meta-Analysis; Systematic Review
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Smothers+CG%22">Smothers CG</searchLink>; School of Nursing, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Gandhi+SA%22">Gandhi SA</searchLink>; School of Medicine, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Chang+JH%22">Chang JH</searchLink>; Department of Orthopedics, Sutter Health, Santa Barbara, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tahir+SM%22">Tahir SM</searchLink>; Department of Dermatology and Plastic Surgery, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Kelley+J%22">Kelley J</searchLink>; Department of Internal Medicine, Stamford Hospital, Stamford, CT, USA.<br /><searchLink fieldCode="AU" term="%22Wang+E%22">Wang E</searchLink>; Department of Neurology, Rush University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Fareed+K%22">Fareed K</searchLink>; School of Medicine, Stanford University, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mack+H%22">Mack H</searchLink>; College of Public Health, Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Dong+C%22">Dong C</searchLink>; Division of Clinical Research Services, Nationwide Children's Hospital, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Witort+M%22">Witort M</searchLink>; College of Arts and Sciences, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Armentrout+BL%22">Armentrout BL</searchLink>; School of Nursing, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Crawford+D%22">Crawford D</searchLink>; School of Science, Technology, and Engineering, Dillard University, New Orleans, LA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Molecular Biomarker Core, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Williams+K%22">Williams K</searchLink>; Molecular Biomarker Core, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Bud+Z%22">Bud Z</searchLink>; School of Nursing, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Horvat-Davey+C%22">Horvat-Davey C</searchLink>; School of Nursing, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Winkelman+C%22">Winkelman C</searchLink>; School of Nursing, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Martha+SR%22">Martha SR</searchLink>; College of Nursing, University of Illinois at Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Schrock+JW%22">Schrock JW</searchLink>; School of Medicine, Case Western Reserve University, Cleveland, OH, USA.; Department of Emergency Medicine, MetroHealth Medical Center, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Ardelt+AA%22">Ardelt AA</searchLink>; School of Medicine, Case Western Reserve University, Cleveland, OH, USA.; Department of Neurology, MetroHealth Medical Center, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22O'Connell+GC%22">O'Connell GC</searchLink>; School of Nursing, Case Western Reserve University, Cleveland, OH, USA. grant.oconnell@case.edu.; Molecular Biomarker Core, Case Western Reserve University, Cleveland, OH, USA. grant.oconnell@case.edu.
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