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Structural mechanism for noncanonical GPCR signaling in the Hedgehog pathway.

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Title: Structural mechanism for noncanonical GPCR signaling in the Hedgehog pathway.
Authors: Steiner WP; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Iverson N; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Liu G; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Venkatakrishnan V; Department of Chemistry, Pennsylvania State University, University Park, PA, USA., Wu J; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA., Stepniewski TM; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM) and Pompeu Fabra University (UPF), Barcelona, Spain.; InterAx Biotech AG, Villigen, Switzerland., Michaelson Z; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.; Idaho College of Osteopathic Medicine, Meridian, ID, USA., Bröckel JW; Department of Biochemistry, Institute for Biology, University of Kassel, Kassel, Germany., Zhu JF; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Bruystens JGH; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA., Lee A; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA., Nelson I; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.; Program in Cell and Molecular Biology, Duke University School of Medicine, Durham, NC, USA., Bertinetti D; Department of Biochemistry, Institute for Biology, University of Kassel, Kassel, Germany., Arveseth CD; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.; Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO, USA., Tan G; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA., Spaltenstein P; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Xu J; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA., Hüttenhain R; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Kay MS; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Herberg FW; Department of Biochemistry, Institute for Biology, University of Kassel, Kassel, Germany., Cao E; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Selent J; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM) and Pompeu Fabra University (UPF), Barcelona, Spain., Anand GS; Department of Chemistry, Pennsylvania State University, University Park, PA, USA.; The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA., Dunbrack RL Jr; Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA. roland.dunbrack@fccc.edu., Taylor SS; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA. staylor@ucsd.edu.; Department of Biochemistry and Molecular Biophysics, University of California, San Diego, La Jolla, CA, USA. staylor@ucsd.edu., Myers BR; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA. benjamin.myers@hci.utah.edu.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA. benjamin.myers@hci.utah.edu.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA. benjamin.myers@hci.utah.edu.
Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2026 May; Vol. 33 (5), pp. 795-809. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Steiner+WP%22">Steiner WP</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Iverson+N%22">Iverson N</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Liu+G%22">Liu G</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; 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