CAR-T cells targeting fibroblast activation protein eliminate pathological fibroblasts and preserve cardiac function in a Duchenne Muscular Dystrophy murine model.
Saved in:
| Title: | CAR-T cells targeting fibroblast activation protein eliminate pathological fibroblasts and preserve cardiac function in a Duchenne Muscular Dystrophy murine model. |
|---|---|
| Authors: | Marigny C; INSERM UMRS 970, Paris Centre de Recherche Cardiovasculaire (PARCC), Univ Paris-Cité, Paris, France., Revet G; Institut de Biologie Paris-Seine (IBPS), CNRS UMR 8263, Inserm U1345, Development, Adaptation and Ageing, Sorbonne Université, 7, quai St Bernard (case 256), 75005, Paris, France., Berger A; INSERM UMRS 970, Paris Centre de Recherche Cardiovasculaire (PARCC), Univ Paris-Cité, Paris, France., Boulch M; Dynamics of Immune Responses Unit, Institut Pasteur, Université Paris Cité, INSERM U1223, Paris, France., Mougenot N; Sorbonne Université, UMS28, Plateforme d'Expérimentation Cœur, Muscles, Vaisseaux, Paris, France., Li Z; Institut de Biologie Paris-Seine (IBPS), CNRS UMR 8263, Inserm U1345, Development, Adaptation and Ageing, Sorbonne Université, 7, quai St Bernard (case 256), 75005, Paris, France., Corre B; Dynamics of Immune Responses Unit, Institut Pasteur, Université Paris Cité, INSERM U1223, Paris, France., Lemaitre M; Sorbonne Université, UMS28, Plateforme d'Expérimentation Cœur, Muscles, Vaisseaux, Paris, France., Bois A; INSERM UMRS 970, Paris Centre de Recherche Cardiovasculaire (PARCC), Univ Paris-Cité, Paris, France., Castelli C; INSERM UMRS 970, Paris Centre de Recherche Cardiovasculaire (PARCC), Univ Paris-Cité, Paris, France., Collombat V; Institut de Biologie Paris-Seine (IBPS), CNRS UMR 8263, Inserm U1345, Development, Adaptation and Ageing, Sorbonne Université, 7, quai St Bernard (case 256), 75005, Paris, France., Parlakian A; Institut de Biologie Paris-Seine (IBPS), CNRS UMR 8263, Inserm U1345, Development, Adaptation and Ageing, Sorbonne Université, 7, quai St Bernard (case 256), 75005, Paris, France., Perier MC; INSERM UMRS 970, Paris Centre de Recherche Cardiovasculaire (PARCC), Univ Paris-Cité, Paris, France., Bot A; Capstan Therapeutics, San Diego, CA, USA., Epstein JA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Lafuste P; IMRB, Inserm U955-Team Relaix, Université Paris Est-Créteil, Créteil, France., Hagege A; INSERM UMRS 970, Paris Centre de Recherche Cardiovasculaire (PARCC), Univ Paris-Cité, Paris, France.; Department of Cardiology, Hôpital Européen Georges Pompidou, Paris, France., Aghajanian H; Capstan Therapeutics, San Diego, CA, USA., Cochain C; INSERM UMRS 970, Paris Centre de Recherche Cardiovasculaire (PARCC), Univ Paris-Cité, Paris, France.; Institute of Experimental Biomedicine, University Hospital Würzburg, Würzburg, Germany., Bousso P; Dynamics of Immune Responses Unit, Institut Pasteur, Université Paris Cité, INSERM U1223, Paris, France., Agbulut O; Institut de Biologie Paris-Seine (IBPS), CNRS UMR 8263, Inserm U1345, Development, Adaptation and Ageing, Sorbonne Université, 7, quai St Bernard (case 256), 75005, Paris, France. onnik.agbulut@sorbonne-universite.fr., Menasché P; INSERM UMRS 970, Paris Centre de Recherche Cardiovasculaire (PARCC), Univ Paris-Cité, Paris, France. philippe.menasche@aphp.fr.; Department of Cardiovascular Surgery, Hôpital Européen Georges Pompidou, 56 rue Leblanc, 75015, Paris, France. philippe.menasche@aphp.fr. |
| Source: | Stem cell research & therapy [Stem Cell Res Ther] 2026 Apr 30; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42063173 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: CAR-T cells targeting fibroblast activation protein eliminate pathological fibroblasts and preserve cardiac function in a Duchenne Muscular Dystrophy murine model. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Marigny+C%22">Marigny C</searchLink>; INSERM UMRS 970, Paris Centre de Recherche Cardiovasculaire (PARCC), Univ Paris-Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Revet+G%22">Revet G</searchLink>; Institut de Biologie Paris-Seine (IBPS), CNRS UMR 8263, Inserm U1345, Development, Adaptation and Ageing, Sorbonne Université, 7, quai St Bernard (case 256), 75005, Paris, France.<br /><searchLink fieldCode="AU" term="%22Berger+A%22">Berger A</searchLink>; INSERM UMRS 970, Paris Centre de Recherche Cardiovasculaire (PARCC), Univ Paris-Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Boulch+M%22">Boulch M</searchLink>; Dynamics of Immune Responses Unit, Institut Pasteur, Université Paris Cité, INSERM U1223, Paris, France.<br /><searchLink fieldCode="AU" term="%22Mougenot+N%22">Mougenot N</searchLink>; Sorbonne Université, UMS28, Plateforme d'Expérimentation Cœur, Muscles, Vaisseaux, Paris, France.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Institut de Biologie Paris-Seine (IBPS), CNRS UMR 8263, Inserm U1345, Development, Adaptation and Ageing, Sorbonne Université, 7, quai St Bernard (case 256), 75005, Paris, France.<br /><searchLink fieldCode="AU" term="%22Corre+B%22">Corre B</searchLink>; Dynamics of Immune Responses Unit, Institut Pasteur, Université Paris Cité, INSERM U1223, Paris, France.<br /><searchLink fieldCode="AU" term="%22Lemaitre+M%22">Lemaitre M</searchLink>; Sorbonne Université, UMS28, Plateforme d'Expérimentation Cœur, Muscles, Vaisseaux, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bois+A%22">Bois A</searchLink>; INSERM UMRS 970, Paris Centre de Recherche Cardiovasculaire (PARCC), Univ Paris-Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Castelli+C%22">Castelli C</searchLink>; INSERM UMRS 970, Paris Centre de Recherche Cardiovasculaire (PARCC), Univ Paris-Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Collombat+V%22">Collombat V</searchLink>; Institut de Biologie Paris-Seine (IBPS), CNRS UMR 8263, Inserm U1345, Development, Adaptation and Ageing, Sorbonne Université, 7, quai St Bernard (case 256), 75005, Paris, France.<br /><searchLink fieldCode="AU" term="%22Parlakian+A%22">Parlakian A</searchLink>; Institut de Biologie Paris-Seine (IBPS), CNRS UMR 8263, Inserm U1345, Development, Adaptation and Ageing, Sorbonne Université, 7, quai St Bernard (case 256), 75005, Paris, France.<br /><searchLink fieldCode="AU" term="%22Perier+MC%22">Perier MC</searchLink>; INSERM UMRS 970, Paris Centre de Recherche Cardiovasculaire (PARCC), Univ Paris-Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bot+A%22">Bot A</searchLink>; Capstan Therapeutics, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Epstein+JA%22">Epstein JA</searchLink>; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lafuste+P%22">Lafuste P</searchLink>; IMRB, Inserm U955-Team Relaix, Université Paris Est-Créteil, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Hagege+A%22">Hagege A</searchLink>; INSERM UMRS 970, Paris Centre de Recherche Cardiovasculaire (PARCC), Univ Paris-Cité, Paris, France.; Department of Cardiology, Hôpital Européen Georges Pompidou, Paris, France.<br /><searchLink fieldCode="AU" term="%22Aghajanian+H%22">Aghajanian H</searchLink>; Capstan Therapeutics, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cochain+C%22">Cochain C</searchLink>; INSERM UMRS 970, Paris Centre de Recherche Cardiovasculaire (PARCC), Univ Paris-Cité, Paris, France.; Institute of Experimental Biomedicine, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bousso+P%22">Bousso P</searchLink>; Dynamics of Immune Responses Unit, Institut Pasteur, Université Paris Cité, INSERM U1223, Paris, France.<br /><searchLink fieldCode="AU" term="%22Agbulut+O%22">Agbulut O</searchLink>; Institut de Biologie Paris-Seine (IBPS), CNRS UMR 8263, Inserm U1345, Development, Adaptation and Ageing, Sorbonne Université, 7, quai St Bernard (case 256), 75005, Paris, France. onnik.agbulut@sorbonne-universite.fr.<br /><searchLink fieldCode="AU" term="%22Menasché+P%22">Menasché P</searchLink>; INSERM UMRS 970, Paris Centre de Recherche Cardiovasculaire (PARCC), Univ Paris-Cité, Paris, France. philippe.menasche@aphp.fr.; Department of Cardiovascular Surgery, Hôpital Européen Georges Pompidou, 56 rue Leblanc, 75015, Paris, France. philippe.menasche@aphp.fr. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101527581%22">Stem cell research & therapy</searchLink> [Stem Cell Res Ther] 2026 Apr 30; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Apr 30. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101527581 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1757-6512 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217576512%22">17576512 </searchLink><i>NLM ISO Abbreviation: </i>Stem Cell Res Ther <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42063173 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s13287-026-05025-1 Languages: – Code: eng Text: English Titles: – TitleFull: CAR-T cells targeting fibroblast activation protein eliminate pathological fibroblasts and preserve cardiac function in a Duchenne Muscular Dystrophy murine model. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Marigny C – PersonEntity: Name: NameFull: Revet G – PersonEntity: Name: NameFull: Berger A – PersonEntity: Name: NameFull: Boulch M – PersonEntity: Name: NameFull: Mougenot N – PersonEntity: Name: NameFull: Li Z – PersonEntity: Name: NameFull: Corre B – PersonEntity: Name: NameFull: Lemaitre M – PersonEntity: Name: NameFull: Bois A – PersonEntity: Name: NameFull: Castelli C – PersonEntity: Name: NameFull: Collombat V – PersonEntity: Name: NameFull: Parlakian A – PersonEntity: Name: NameFull: Perier MC – PersonEntity: Name: NameFull: Bot A – PersonEntity: Name: NameFull: Epstein JA – PersonEntity: Name: NameFull: Lafuste P – PersonEntity: Name: NameFull: Hagege A – PersonEntity: Name: NameFull: Aghajanian H – PersonEntity: Name: NameFull: Cochain C – PersonEntity: Name: NameFull: Bousso P – PersonEntity: Name: NameFull: Agbulut O – PersonEntity: Name: NameFull: Menasché P IsPartOfRelationships: – BibEntity: Dates: – D: 30 M: 04 Text: 2026 Apr 30 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1757-6512 Numbering: – Type: volume Value: 17 – Type: issue Value: 1 Titles: – TitleFull: Stem cell research & therapy Type: main |
| ResultId | 1 |
