The In Vivo Effect of Amorphous Drug Nanoprecipitates on the Intestinal Absorption of the PROTACs ARV-110 (Bavdeglutamide) and ARV-471 (Vepdegestrant).
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| Title: | The In Vivo Effect of Amorphous Drug Nanoprecipitates on the Intestinal Absorption of the PROTACs ARV-110 (Bavdeglutamide) and ARV-471 (Vepdegestrant). |
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| Authors: | Niessen J; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala 751 05, Sweden., Koziolek M; Synthetic Molecules CMC R&D, AbbVie Deutschland GmbH & Co. KG, Knollstrasse, Ludwigshafen am Rhein 67061, Germany., Indulkar A; AbbVie Small Molecule CMC Development, 1N Waukegan Road, North Chicago 07065, Illinois, United States., Borchardt T; AbbVie Product Development Science and Technology, 1N Waukegan Road, North Chicago 07065, Illinois, United States., Sjöblom M; Department of Medical Cell Biology, Uppsala University, Uppsala 751 05, Sweden., Hedeland M; Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry, Uppsala University, Uppsala 751 05, Sweden., Lennernäs H; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala 751 05, Sweden., Dahlgren D; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala 751 05, Sweden. |
| Source: | Molecular pharmaceutics [Mol Pharm] 2026 Jun 01; Vol. 23 (6), pp. 3445-3457. Date of Electronic Publication: 2026 Apr 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42063283 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The In Vivo Effect of Amorphous Drug Nanoprecipitates on the Intestinal Absorption of the PROTACs ARV-110 (Bavdeglutamide) and ARV-471 (Vepdegestrant). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Niessen+J%22">Niessen J</searchLink>; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala 751 05, Sweden.<br /><searchLink fieldCode="AU" term="%22Koziolek+M%22">Koziolek M</searchLink>; Synthetic Molecules CMC R&D, AbbVie Deutschland GmbH & Co. KG, Knollstrasse, Ludwigshafen am Rhein 67061, Germany.<br /><searchLink fieldCode="AU" term="%22Indulkar+A%22">Indulkar A</searchLink>; AbbVie Small Molecule CMC Development, 1N Waukegan Road, North Chicago 07065, Illinois, United States.<br /><searchLink fieldCode="AU" term="%22Borchardt+T%22">Borchardt T</searchLink>; AbbVie Product Development Science and Technology, 1N Waukegan Road, North Chicago 07065, Illinois, United States.<br /><searchLink fieldCode="AU" term="%22Sjöblom+M%22">Sjöblom M</searchLink>; Department of Medical Cell Biology, Uppsala University, Uppsala 751 05, Sweden.<br /><searchLink fieldCode="AU" term="%22Hedeland+M%22">Hedeland M</searchLink>; Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry, Uppsala University, Uppsala 751 05, Sweden.<br /><searchLink fieldCode="AU" term="%22Lennernäs+H%22">Lennernäs H</searchLink>; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala 751 05, Sweden.<br /><searchLink fieldCode="AU" term="%22Dahlgren+D%22">Dahlgren D</searchLink>; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala 751 05, Sweden. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101197791%22">Molecular pharmaceutics</searchLink> [Mol Pharm] 2026 Jun 01; Vol. 23 (6), pp. 3445-3457. <i>Date of Electronic Publication: </i>2026 Apr 30. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101197791 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1543-8392 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215438384%22">15438384 </searchLink><i>NLM ISO Abbreviation: </i>Mol Pharm <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42063283 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acs.molpharmaceut.6c00207 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 3445 Titles: – TitleFull: The In Vivo Effect of Amorphous Drug Nanoprecipitates on the Intestinal Absorption of the PROTACs ARV-110 (Bavdeglutamide) and ARV-471 (Vepdegestrant). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Niessen J – PersonEntity: Name: NameFull: Koziolek M – PersonEntity: Name: NameFull: Indulkar A – PersonEntity: Name: NameFull: Borchardt T – PersonEntity: Name: NameFull: Sjöblom M – PersonEntity: Name: NameFull: Hedeland M – PersonEntity: Name: NameFull: Lennernäs H – PersonEntity: Name: NameFull: Dahlgren D IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: 2026 Jun 01 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1543-8392 Numbering: – Type: volume Value: 23 – Type: issue Value: 6 Titles: – TitleFull: Molecular pharmaceutics Type: main |
| ResultId | 1 |
