Does Thyroid Hormone Boost Energy and Plasticity in the Brain as a Mechanism of Action in Antidepressant Augmentation Therapy?

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Title: Does Thyroid Hormone Boost Energy and Plasticity in the Brain as a Mechanism of Action in Antidepressant Augmentation Therapy?
Authors: McIntyre RS; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada., Mathew SJ; Department of Psychiatry & Behavioral Sciences, Texas A&M Naresh K. Vashist College of Medicine, Bryan, Texas, USA., Scanlan TS; Department of Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, Oregon, USA.
Source: Thyroid : official journal of the American Thyroid Association [Thyroid] 2026 Aug; Vol. 36 (8), pp. 827-831. Date of Electronic Publication: 2026 May 01.
Publication Type: Journal Article; Review
Journal Info: Publisher: Mary Ann Liebert Publishers Country of Publication: United States NLM ID: 9104317 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-9077 (Electronic) Linking ISSN: 10507256 NLM ISO Abbreviation: Thyroid Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22McIntyre+RS%22">McIntyre RS</searchLink>; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Mathew+SJ%22">Mathew SJ</searchLink>; Department of Psychiatry & Behavioral Sciences, Texas A&M Naresh K. Vashist College of Medicine, Bryan, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Scanlan+TS%22">Scanlan TS</searchLink>; Department of Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, Oregon, USA.
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  Data: <searchLink fieldCode="JN" term="%229104317%22">Thyroid : official journal of the American Thyroid Association</searchLink> [Thyroid] 2026 Aug; Vol. 36 (8), pp. 827-831. <i>Date of Electronic Publication: </i>2026 May 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Mary+Ann+Liebert+Publishers%22">Mary Ann Liebert Publishers </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9104317 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-9077 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210507256%22">10507256 </searchLink><i>NLM ISO Abbreviation: </i>Thyroid <i>Subsets: </i>MEDLINE
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        Value: 10.1177/10507256261448290
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      – Code: eng
        Text: English
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        StartPage: 827
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      – TitleFull: Does Thyroid Hormone Boost Energy and Plasticity in the Brain as a Mechanism of Action in Antidepressant Augmentation Therapy?
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            – D: 01
              M: 08
              Text: 2026 Aug
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              Y: 2026
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