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Japanese encephalitis virus NS1 and NS4B synergistically target TLR3 signaling to promote viral replication.

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Title: Japanese encephalitis virus NS1 and NS4B synergistically target TLR3 signaling to promote viral replication.
Authors: Zeng Q; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China., He M; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China., Li M; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China., Yang D; Xianghu Laboratory, Hangzhou, Zhejiang, China., Wang L; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, and Pandemic Research Alliance at The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China., Hao C; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China., Wang Z; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China., Zhou M; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, and Pandemic Research Alliance at The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China., Zhu T; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, and Pandemic Research Alliance at The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China., Niu X; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China., Chen Z; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China., Zhang B; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China., Zu S; College of Veterinary Medicine, Henan Agricultural University, Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Henan Province Key Laboratory of Animal Food Pathogens Surveillance, Zhengzhou, China., Ding X; College of Veterinary Medicine, Henan Agricultural University, Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Henan Province Key Laboratory of Animal Food Pathogens Surveillance, Zhengzhou, China., Wei Z; College of Veterinary Medicine, Henan Agricultural University, Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Henan Province Key Laboratory of Animal Food Pathogens Surveillance, Zhengzhou, China., Chu H; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, and Pandemic Research Alliance at The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.; InnoHK (Center for Virology, Vaccinology, and Therapeutics), Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, Hong Kong, China.; Materials Innovation Institute for Life Sciences and Energy (MILES), HKU-SIRI, Shenzhen, China., Zhang H; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, and Pandemic Research Alliance at The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.; College of Veterinary Medicine, Henan Agricultural University, Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Henan Province Key Laboratory of Animal Food Pathogens Surveillance, Zhengzhou, China.
Source: MBio [mBio] 2026 Jun 10; Vol. 17 (6), pp. e0360425. Date of Electronic Publication: 2026 May 01.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Japanese encephalitis virus NS1 and NS4B synergistically target TLR3 signaling to promote viral replication.
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  Data: <searchLink fieldCode="AU" term="%22Zeng+Q%22">Zeng Q</searchLink>; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22He+M%22">He M</searchLink>; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Yang+D%22">Yang D</searchLink>; Xianghu Laboratory, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, and Pandemic Research Alliance at The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Hao+C%22">Hao C</searchLink>; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhou+M%22">Zhou M</searchLink>; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, and Pandemic Research Alliance at The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Zhu+T%22">Zhu T</searchLink>; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, and Pandemic Research Alliance at The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Niu+X%22">Niu X</searchLink>; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Zu+S%22">Zu S</searchLink>; College of Veterinary Medicine, Henan Agricultural University, Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Henan Province Key Laboratory of Animal Food Pathogens Surveillance, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Ding+X%22">Ding X</searchLink>; College of Veterinary Medicine, Henan Agricultural University, Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Henan Province Key Laboratory of Animal Food Pathogens Surveillance, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Wei+Z%22">Wei Z</searchLink>; College of Veterinary Medicine, Henan Agricultural University, Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Henan Province Key Laboratory of Animal Food Pathogens Surveillance, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Chu+H%22">Chu H</searchLink>; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, and Pandemic Research Alliance at The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.; InnoHK (Center for Virology, Vaccinology, and Therapeutics), Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, Hong Kong, China.; Materials Innovation Institute for Life Sciences and Energy (MILES), HKU-SIRI, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, and Pandemic Research Alliance at The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.; College of Veterinary Medicine, Henan Agricultural University, Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Henan Province Key Laboratory of Animal Food Pathogens Surveillance, Zhengzhou, China.
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  Data: <searchLink fieldCode="JN" term="%22101519231%22">MBio</searchLink> [mBio] 2026 Jun 10; Vol. 17 (6), pp. e0360425. <i>Date of Electronic Publication: </i>2026 May 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Microbiology%22">American Society for Microbiology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101519231 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2150-7511 (Electronic) <i>NLM ISO Abbreviation: </i>mBio <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42065594
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        Value: 10.1128/mbio.03604-25
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              Text: 2026 Jun 10
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