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Distinct in vivo dynamics of donor-derived stem cell memory CAR T cells post-allogeneic HSCT relapse.

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Title: Distinct in vivo dynamics of donor-derived stem cell memory CAR T cells post-allogeneic HSCT relapse.
Authors: Gattinoni L; Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; University of Regensburg, Regensburg, Germany; Center for Immunomedicine in Transplantation and Oncology, University Hospital Regensburg, Regensburg, Germany. Electronic address: luca.gattinoni@lit.eu., Inchingolo G; Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany., Harrer DC; Department of Internal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany., Susana A; IRCCS Humanitas Research Hospital, Rozzano, Italy., Puccio S; IRCCS Humanitas Research Hospital, Rozzano, Italy; Institute of Genetics and Biomedical Research, Milan Unit, Consiglio Nazionale delle Ricerche, Rozzano, Italy., Slavkovic-Lukic D; Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany., Natrakul DA; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Strieder N; Next Generation Sequencing Core, Leibniz Institute for Immunotherapy, Regensburg, Germany., Heuser-Loy C; Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany., Baldwin JG; Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany., Fioravanti J; Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Ji Y; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Gautam S; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Suriano C; Epigenetic Immuno-Oncology Group, Leibniz Institute for Immunotherapy, Regensburg, Germany., Martín-Santos A; Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany., Schelker RC; Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany; Department of Internal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany., Patel N; Hematology Section, Department of Laboratory Medicine, National Institutes of Health, Clinical Center, Bethesda, MD, USA., Mann J; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Goff S; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Mikkilineni L; Division of Bone and Marrow Transplantation & Cellular Therapies, Stanford University School of Medicine, Palo Alto, CA, USA., Yang JC; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Kwong MLM; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Patel R; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Rehli M; Department of Internal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany; Next Generation Sequencing Core, Leibniz Institute for Immunotherapy, Regensburg, Germany., Highfill SL; Department of Transfusion Medicine, National Institutes of Health, Clinical Center, Bethesda, MD, USA., Stroncek DF; Department of Transfusion Medicine, National Institutes of Health, Clinical Center, Bethesda, MD, USA., Rosenberg SA; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Biasco L; Faculty of Population Health Science, Department of Infection Immunity and Inflammation, Zayed Centre for Research, University College of London, London, UK., Lugli E; IRCCS Humanitas Research Hospital, Rozzano, Italy., Brudno JN; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Kochenderfer JN; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: kochendj@mail.nih.gov.
Source: Cell [Cell] 2026 Jun 11; Vol. 189 (12), pp. 3686-3700.e10. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Clinical Trial, Phase I; Journal Article; Multicenter Study
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Distinct in vivo dynamics of donor-derived stem cell memory CAR T cells post-allogeneic HSCT relapse.
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  Data: <searchLink fieldCode="AU" term="%22Gattinoni+L%22">Gattinoni L</searchLink>; Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; University of Regensburg, Regensburg, Germany; Center for Immunomedicine in Transplantation and Oncology, University Hospital Regensburg, Regensburg, Germany. Electronic address: luca.gattinoni@lit.eu.<br /><searchLink fieldCode="AU" term="%22Inchingolo+G%22">Inchingolo G</searchLink>; Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Harrer+DC%22">Harrer DC</searchLink>; Department of Internal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Susana+A%22">Susana A</searchLink>; IRCCS Humanitas Research Hospital, Rozzano, Italy.<br /><searchLink fieldCode="AU" term="%22Puccio+S%22">Puccio S</searchLink>; IRCCS Humanitas Research Hospital, Rozzano, Italy; Institute of Genetics and Biomedical Research, Milan Unit, Consiglio Nazionale delle Ricerche, Rozzano, Italy.<br /><searchLink fieldCode="AU" term="%22Slavkovic-Lukic+D%22">Slavkovic-Lukic D</searchLink>; Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Natrakul+DA%22">Natrakul DA</searchLink>; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Strieder+N%22">Strieder N</searchLink>; Next Generation Sequencing Core, Leibniz Institute for Immunotherapy, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Heuser-Loy+C%22">Heuser-Loy C</searchLink>; Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Baldwin+JG%22">Baldwin JG</searchLink>; Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Fioravanti+J%22">Fioravanti J</searchLink>; Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ji+Y%22">Ji Y</searchLink>; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gautam+S%22">Gautam S</searchLink>; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Suriano+C%22">Suriano C</searchLink>; Epigenetic Immuno-Oncology Group, Leibniz Institute for Immunotherapy, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Martín-Santos+A%22">Martín-Santos A</searchLink>; Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schelker+RC%22">Schelker RC</searchLink>; Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany; Department of Internal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Patel+N%22">Patel N</searchLink>; Hematology Section, Department of Laboratory Medicine, National Institutes of Health, Clinical Center, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Mann+J%22">Mann J</searchLink>; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Goff+S%22">Goff S</searchLink>; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Mikkilineni+L%22">Mikkilineni L</searchLink>; Division of Bone and Marrow Transplantation & Cellular Therapies, Stanford University School of Medicine, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+JC%22">Yang JC</searchLink>; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kwong+MLM%22">Kwong MLM</searchLink>; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Patel+R%22">Patel R</searchLink>; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Rehli+M%22">Rehli M</searchLink>; Department of Internal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany; Next Generation Sequencing Core, Leibniz Institute for Immunotherapy, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Highfill+SL%22">Highfill SL</searchLink>; Department of Transfusion Medicine, National Institutes of Health, Clinical Center, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Stroncek+DF%22">Stroncek DF</searchLink>; Department of Transfusion Medicine, National Institutes of Health, Clinical Center, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Rosenberg+SA%22">Rosenberg SA</searchLink>; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Biasco+L%22">Biasco L</searchLink>; Faculty of Population Health Science, Department of Infection Immunity and Inflammation, Zayed Centre for Research, University College of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Lugli+E%22">Lugli E</searchLink>; IRCCS Humanitas Research Hospital, Rozzano, Italy.<br /><searchLink fieldCode="AU" term="%22Brudno+JN%22">Brudno JN</searchLink>; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kochenderfer+JN%22">Kochenderfer JN</searchLink>; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: kochendj@mail.nih.gov.
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  Data: <searchLink fieldCode="JN" term="%220413066%22">Cell</searchLink> [Cell] 2026 Jun 11; Vol. 189 (12), pp. 3686-3700.e10. <i>Date of Electronic Publication: </i>2026 Apr 30.
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