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Treatment Dose Increase Versus Co-Medication in Allergic Rhinitis: Systematic Review With Dose-Response Network Meta-Analysis.

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Title: Treatment Dose Increase Versus Co-Medication in Allergic Rhinitis: Systematic Review With Dose-Response Network Meta-Analysis.
Authors: Sousa-Pinto B; MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto, Porto, Portugal.; CINTESIS@RISE-Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal., Vieira RJ; MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto, Porto, Portugal.; CINTESIS@RISE-Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal., Gil-Mata S; MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto, Porto, Portugal.; CINTESIS@RISE-Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal., Pereira AM; MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto, Porto, Portugal.; CINTESIS@RISE-Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.; Allergy Unit, Instituto and Hospital CUF, Porto, Portugal., Duarte VH; MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto, Porto, Portugal.; CINTESIS@RISE-Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.; Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal., Bognanni A; Clinical Epidemiology and Research Center (CERC), Humanitas University and Humanitas Research Hospital, Milan, Italy.; Department of Health Research Methods, Evidence, and Impact & Department of Medicine, Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada., Marques-Cruz M; MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto, Porto, Portugal.; CINTESIS@RISE-Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal., Jemioło P; AGH (Akademia Gorniczo-Hutnicza) University of Krakow, Krakow, Poland.; Chair of Epidemiology and Preventive Medicine, Department of Hygiene and Dietetics, Faculty of Medicine Jagiellonian University Medical College, Krakow, Poland., Giovannini M; Allergy Unit, Meyer Children's Hospital IRCCS, Florence, Italy.; Department of Health Sciences, University of Florence, Florence, Italy., di Bona D; Department of Medical and Surgical Science, University of Foggia, Foggia, Italy., Agarwal A; Division of General Internal Medicine, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada., Dykewicz MS; Section of Allergy and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA., Shamji MH; National Heart and Lung Institute (NHLI), Imperial College, London, UK.; NIHR Imperial Biomedical Research Centre, London, UK., Torres MJ; Allergy Unit, Regional University Hospital of Málaga, Malaga University, ARADyAL, Malaga, Spain., Zuberbier T; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany., Klimek L; Department of Otolaryngology, Head & Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany.; Center for Rhinology and Allergology, Wiesbaden, Germany., Chu AWL; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada., Schünemann HJ; Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal.; Clinical Epidemiology and Research Center (CERC), Humanitas University and Humanitas Research Hospital, Milan, Italy.; Department of Health Research Methods, Evidence, and Impact & Department of Medicine, Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany., Schwarzer G; Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany., Fonseca JA; MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto, Porto, Portugal.; CINTESIS@RISE-Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.; Allergy Unit, Instituto and Hospital CUF, Porto, Portugal., Bousquet J; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.; ARIA (Allergic Rhinitis and Its Impact on Asthma), Montpellier, France.
Corporate Authors: ARIA 2024–2025 systematic reviews group
Source: Allergy [Allergy] 2026 May 01. Date of Electronic Publication: 2026 May 01.
Publication Type: Journal Article; Review
Journal Info: Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 7804028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1398-9995 (Electronic) Linking ISSN: 01054538 NLM ISO Abbreviation: Allergy Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Treatment Dose Increase Versus Co-Medication in Allergic Rhinitis: Systematic Review With Dose-Response Network Meta-Analysis.
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  Data: <searchLink fieldCode="AU" term="%22Sousa-Pinto+B%22">Sousa-Pinto B</searchLink>; MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto, Porto, Portugal.; CINTESIS@RISE-Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Vieira+RJ%22">Vieira RJ</searchLink>; MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto, Porto, Portugal.; CINTESIS@RISE-Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Gil-Mata+S%22">Gil-Mata S</searchLink>; MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto, Porto, Portugal.; CINTESIS@RISE-Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Pereira+AM%22">Pereira AM</searchLink>; MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto, Porto, Portugal.; CINTESIS@RISE-Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.; Allergy Unit, Instituto and Hospital CUF, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Duarte+VH%22">Duarte VH</searchLink>; MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto, Porto, Portugal.; CINTESIS@RISE-Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.; Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Bognanni+A%22">Bognanni A</searchLink>; Clinical Epidemiology and Research Center (CERC), Humanitas University and Humanitas Research Hospital, Milan, Italy.; Department of Health Research Methods, Evidence, and Impact & Department of Medicine, Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Marques-Cruz+M%22">Marques-Cruz M</searchLink>; MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto, Porto, Portugal.; CINTESIS@RISE-Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Jemioło+P%22">Jemioło P</searchLink>; AGH (Akademia Gorniczo-Hutnicza) University of Krakow, Krakow, Poland.; Chair of Epidemiology and Preventive Medicine, Department of Hygiene and Dietetics, Faculty of Medicine Jagiellonian University Medical College, Krakow, Poland.<br /><searchLink fieldCode="AU" term="%22Giovannini+M%22">Giovannini M</searchLink>; Allergy Unit, Meyer Children's Hospital IRCCS, Florence, Italy.; Department of Health Sciences, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22di+Bona+D%22">di Bona D</searchLink>; Department of Medical and Surgical Science, University of Foggia, Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Agarwal+A%22">Agarwal A</searchLink>; Division of General Internal Medicine, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Dykewicz+MS%22">Dykewicz MS</searchLink>; Section of Allergy and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Shamji+MH%22">Shamji MH</searchLink>; National Heart and Lung Institute (NHLI), Imperial College, London, UK.; NIHR Imperial Biomedical Research Centre, London, UK.<br /><searchLink fieldCode="AU" term="%22Torres+MJ%22">Torres MJ</searchLink>; Allergy Unit, Regional University Hospital of Málaga, Malaga University, ARADyAL, Malaga, Spain.<br /><searchLink fieldCode="AU" term="%22Zuberbier+T%22">Zuberbier T</searchLink>; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Klimek+L%22">Klimek L</searchLink>; Department of Otolaryngology, Head & Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany.; Center for Rhinology and Allergology, Wiesbaden, Germany.<br /><searchLink fieldCode="AU" term="%22Chu+AWL%22">Chu AWL</searchLink>; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Schünemann+HJ%22">Schünemann HJ</searchLink>; Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal.; Clinical Epidemiology and Research Center (CERC), Humanitas University and Humanitas Research Hospital, Milan, Italy.; Department of Health Research Methods, Evidence, and Impact & Department of Medicine, Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Schwarzer+G%22">Schwarzer G</searchLink>; Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Fonseca+JA%22">Fonseca JA</searchLink>; MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto, Porto, Portugal.; CINTESIS@RISE-Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.; Allergy Unit, Instituto and Hospital CUF, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Bousquet+J%22">Bousquet J</searchLink>; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.; ARIA (Allergic Rhinitis and Its Impact on Asthma), Montpellier, France.
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