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mRNA delivery of mosaic-8 pan-sarbecovirus RBD vaccines elicits distinct antibody epitope signatures.

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Title: mRNA delivery of mosaic-8 pan-sarbecovirus RBD vaccines elicits distinct antibody epitope signatures.
Authors: Cohen AA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Keeffe JR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Manasyan L; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Madireddy I; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Priso Fils AI; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Dam KA; Gladstone Institutes, San Francisco, CA 94158, USA., Stober HE; Gladstone Institutes, San Francisco, CA 94158, USA., Hills RA; Department of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD Cambridge, UK; Department of Biochemistry, University of Oxford, OX1 3QU Oxford, UK., Moon WJ; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada., Lin PJC; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada., Howarth MR; Department of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD Cambridge, UK., Hoffmann MAG; Gladstone Institutes, San Francisco, CA 94158, USA; Department of Medicine, University, San Francisco, CA 94143, USA. Electronic address: magnus.hoffmann@gladstone.ucsf.edu., Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: bjorkman@caltech.edu.
Source: Cell reports [Cell Rep] 2026 May 26; Vol. 45 (5), pp. 117335. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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  Data: mRNA delivery of mosaic-8 pan-sarbecovirus RBD vaccines elicits distinct antibody epitope signatures.
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  Data: <searchLink fieldCode="AU" term="%22Cohen+AA%22">Cohen AA</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.<br /><searchLink fieldCode="AU" term="%22Keeffe+JR%22">Keeffe JR</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.<br /><searchLink fieldCode="AU" term="%22Manasyan+L%22">Manasyan L</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.<br /><searchLink fieldCode="AU" term="%22Madireddy+I%22">Madireddy I</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.<br /><searchLink fieldCode="AU" term="%22Priso+Fils+AI%22">Priso Fils AI</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.<br /><searchLink fieldCode="AU" term="%22Dam+KA%22">Dam KA</searchLink>; Gladstone Institutes, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Stober+HE%22">Stober HE</searchLink>; Gladstone Institutes, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Hills+RA%22">Hills RA</searchLink>; Department of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD Cambridge, UK; Department of Biochemistry, University of Oxford, OX1 3QU Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Moon+WJ%22">Moon WJ</searchLink>; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada.<br /><searchLink fieldCode="AU" term="%22Lin+PJC%22">Lin PJC</searchLink>; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada.<br /><searchLink fieldCode="AU" term="%22Howarth+MR%22">Howarth MR</searchLink>; Department of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Hoffmann+MAG%22">Hoffmann MAG</searchLink>; Gladstone Institutes, San Francisco, CA 94158, USA; Department of Medicine, University, San Francisco, CA 94143, USA. Electronic address: magnus.hoffmann@gladstone.ucsf.edu.<br /><searchLink fieldCode="AU" term="%22Bjorkman+PJ%22">Bjorkman PJ</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: bjorkman@caltech.edu.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2026 May 26; Vol. 45 (5), pp. 117335. <i>Date of Electronic Publication: </i>2026 Apr 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101573691 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2211-1247 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Rep <i>Subsets: </i>MEDLINE
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