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Development and validation of a semi-automated hybrid immunocapture liquid chromatography-mass spectrometry method to quantify LALA-mutated biotherapeutics in mouse plasma.

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Title: Development and validation of a semi-automated hybrid immunocapture liquid chromatography-mass spectrometry method to quantify LALA-mutated biotherapeutics in mouse plasma.
Authors: Papa V; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy; University of Turin, Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy. Electronic address: vittoria.papa@external.merckgroup.com., De Salve I; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy., Molinaro F; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy., Ianni AD; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy; University of Turin, Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy., Monge S; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy., Mastroianni R; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy., Ariaudo A; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy., Tavano P; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy., Castagna V; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy., Cowan K; New Biological Entities, Drug Metabolism and Pharmacokinetics (NBE-DMPK), Research and Development, Merck KGaA, Frankfurterstrasse 250, 64293 Darmstadt, Germany., Sirtori FR; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy. Electronic address: federico.riccardi-sirtori@merckgroup.com.
Source: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2026 Aug 01; Vol. 223, pp. 107540. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article; Validation Study
Journal Info: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Development and validation of a semi-automated hybrid immunocapture liquid chromatography-mass spectrometry method to quantify LALA-mutated biotherapeutics in mouse plasma.
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  Data: <searchLink fieldCode="AU" term="%22Papa+V%22">Papa V</searchLink>; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy; University of Turin, Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy. Electronic address: vittoria.papa@external.merckgroup.com.<br /><searchLink fieldCode="AU" term="%22De+Salve+I%22">De Salve I</searchLink>; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy.<br /><searchLink fieldCode="AU" term="%22Molinaro+F%22">Molinaro F</searchLink>; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy.<br /><searchLink fieldCode="AU" term="%22Ianni+AD%22">Ianni AD</searchLink>; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy; University of Turin, Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Monge+S%22">Monge S</searchLink>; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy.<br /><searchLink fieldCode="AU" term="%22Mastroianni+R%22">Mastroianni R</searchLink>; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy.<br /><searchLink fieldCode="AU" term="%22Ariaudo+A%22">Ariaudo A</searchLink>; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy.<br /><searchLink fieldCode="AU" term="%22Tavano+P%22">Tavano P</searchLink>; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy.<br /><searchLink fieldCode="AU" term="%22Castagna+V%22">Castagna V</searchLink>; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy.<br /><searchLink fieldCode="AU" term="%22Cowan+K%22">Cowan K</searchLink>; New Biological Entities, Drug Metabolism and Pharmacokinetics (NBE-DMPK), Research and Development, Merck KGaA, Frankfurterstrasse 250, 64293 Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Sirtori+FR%22">Sirtori FR</searchLink>; NBE-DMPK Innovative Bioanalytic, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy. Electronic address: federico.riccardi-sirtori@merckgroup.com.
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              Text: 2026 Aug 01
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