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Structural flexibility of the human vault particle revealed by high-resolution cryo-EM and molecular dynamics simulations.

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Title: Structural flexibility of the human vault particle revealed by high-resolution cryo-EM and molecular dynamics simulations.
Authors: Lapenta F; Laboratory for Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 13, Nova Gorica, Slovenia. fabio.lapenta@ung.si.; International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, Trieste, Italy. fabio.lapenta@ung.si., Palacio-Rodriguez K; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue-Straße 3, Frankfurt am Main, Germany., Cruz-León S; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue-Straße 3, Frankfurt am Main, Germany., Marrancone S; Laboratory for Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 13, Nova Gorica, Slovenia., Aupič J; Istituto Officina dei Materiali, Consiglio Nazionale delle Ricerche - c/o International School for Advanced Studies, via Bonomea 265, Trieste, Italy., Marechal N; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Parc D'Innovation 1 Rue Laurent Fries, Illkirch Cedex, France., Durand A; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Parc D'Innovation 1 Rue Laurent Fries, Illkirch Cedex, France., Moussaoui D; BM29 BIOSAXS beamline, European Synchrotron Radiation Facility (ESRF), Grenoble, France.; EMBL Grenoble, 71 Avenue des Martyrs, 38042, Grenoble, France., Covaceuszach S; Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Strada Statale 14 km 163.5, Trieste, Italy., Gangupam B; Laboratory for Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 13, Nova Gorica, Slovenia., D'Ercole C; Laboratory for Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 13, Nova Gorica, Slovenia., Parra C; Max Planck Tandem Group Biophysics of Tropical Diseases, Faculty of Exact and Natural Sciences, University of Antioquia, Medellín, Colombia., Cotugno D; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milano, Italy.; IEO, European Institute of Oncology IRCCS, Department of Experimental Oncology, Milan, Italy., Tomaino G; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milano, Italy., Tortora P; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milano, Italy., de Marco A; Laboratory for Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 13, Nova Gorica, Slovenia., Cassetta A; Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Strada Statale 14 km 163.5, Trieste, Italy., Magistrato A; Istituto Officina dei Materiali, Consiglio Nazionale delle Ricerche - c/o International School for Advanced Studies, via Bonomea 265, Trieste, Italy., Hummer G; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue-Straße 3, Frankfurt am Main, Germany.; Institute of Biophysics, Goethe University Frankfurt, Frankfurt am Main, Germany.
Source: Nature communications [Nat Commun] 2026 May 02; Vol. 17 (1). Date of Electronic Publication: 2026 May 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Lapenta+F%22">Lapenta F</searchLink>; Laboratory for Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 13, Nova Gorica, Slovenia. fabio.lapenta@ung.si.; International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, Trieste, Italy. fabio.lapenta@ung.si.<br /><searchLink fieldCode="AU" term="%22Palacio-Rodriguez+K%22">Palacio-Rodriguez K</searchLink>; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue-Straße 3, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Cruz-León+S%22">Cruz-León S</searchLink>; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue-Straße 3, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Marrancone+S%22">Marrancone S</searchLink>; Laboratory for Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 13, Nova Gorica, Slovenia.<br /><searchLink fieldCode="AU" term="%22Aupič+J%22">Aupič J</searchLink>; Istituto Officina dei Materiali, Consiglio Nazionale delle Ricerche - c/o International School for Advanced Studies, via Bonomea 265, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Marechal+N%22">Marechal N</searchLink>; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Parc D'Innovation 1 Rue Laurent Fries, Illkirch Cedex, France.<br /><searchLink fieldCode="AU" term="%22Durand+A%22">Durand A</searchLink>; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Parc D'Innovation 1 Rue Laurent Fries, Illkirch Cedex, France.<br /><searchLink fieldCode="AU" term="%22Moussaoui+D%22">Moussaoui D</searchLink>; BM29 BIOSAXS beamline, European Synchrotron Radiation Facility (ESRF), Grenoble, France.; EMBL Grenoble, 71 Avenue des Martyrs, 38042, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Covaceuszach+S%22">Covaceuszach S</searchLink>; Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Strada Statale 14 km 163.5, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Gangupam+B%22">Gangupam B</searchLink>; Laboratory for Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 13, Nova Gorica, Slovenia.<br /><searchLink fieldCode="AU" term="%22D'Ercole+C%22">D'Ercole C</searchLink>; Laboratory for Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 13, Nova Gorica, Slovenia.<br /><searchLink fieldCode="AU" term="%22Parra+C%22">Parra C</searchLink>; Max Planck Tandem Group Biophysics of Tropical Diseases, Faculty of Exact and Natural Sciences, University of Antioquia, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Cotugno+D%22">Cotugno D</searchLink>; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milano, Italy.; IEO, European Institute of Oncology IRCCS, Department of Experimental Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Tomaino+G%22">Tomaino G</searchLink>; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Tortora+P%22">Tortora P</searchLink>; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22de+Marco+A%22">de Marco A</searchLink>; Laboratory for Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 13, Nova Gorica, Slovenia.<br /><searchLink fieldCode="AU" term="%22Cassetta+A%22">Cassetta A</searchLink>; Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Strada Statale 14 km 163.5, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Magistrato+A%22">Magistrato A</searchLink>; Istituto Officina dei Materiali, Consiglio Nazionale delle Ricerche - c/o International School for Advanced Studies, via Bonomea 265, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Hummer+G%22">Hummer G</searchLink>; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue-Straße 3, Frankfurt am Main, Germany.; Institute of Biophysics, Goethe University Frankfurt, Frankfurt am Main, Germany.
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