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Vitamin K2 Extends Lifespan by Alleviating Mitochondrial Stress via the JNK-1/SIR-2.1/DAF-16 Signaling Axis in Caenorhabditis elegans.

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Title: Vitamin K2 Extends Lifespan by Alleviating Mitochondrial Stress via the JNK-1/SIR-2.1/DAF-16 Signaling Axis in Caenorhabditis elegans.
Authors: Guo SY; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Li YQ; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Piao H; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Zheng WF; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Li SQ; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Liu ZY; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Lv JT; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Kong Y; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Li QF; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Wang YZ; Department of International Medical Services, Second Affiliated Hospital of Dalian Medical University, Dalian, China., Li SZ; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Zhao CL; Department of Critical Care Medicine, Affiliated Dalian Friendship Hospital of Dalian Medical University, Dalian, China., Li S; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.
Source: Aging cell [Aging Cell] 2026 May; Vol. 25 (5), pp. e70530.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Vitamin K2 Extends Lifespan by Alleviating Mitochondrial Stress via the JNK-1/SIR-2.1/DAF-16 Signaling Axis in Caenorhabditis elegans.
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  Data: <searchLink fieldCode="AU" term="%22Guo+SY%22">Guo SY</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Li+YQ%22">Li YQ</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Piao+H%22">Piao H</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Zheng+WF%22">Zheng WF</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Li+SQ%22">Li SQ</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Liu+ZY%22">Liu ZY</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Lv+JT%22">Lv JT</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Kong+Y%22">Kong Y</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Li+QF%22">Li QF</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Wang+YZ%22">Wang YZ</searchLink>; Department of International Medical Services, Second Affiliated Hospital of Dalian Medical University, Dalian, China.<br /><searchLink fieldCode="AU" term="%22Li+SZ%22">Li SZ</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Zhao+CL%22">Zhao CL</searchLink>; Department of Critical Care Medicine, Affiliated Dalian Friendship Hospital of Dalian Medical University, Dalian, China.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.
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              Text: 2026 May
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