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The use of pharmacotherapies in non-cirrhotic metabolic dysfunction-associated steatohepatitis: a UK expert consensus.

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Title: The use of pharmacotherapies in non-cirrhotic metabolic dysfunction-associated steatohepatitis: a UK expert consensus.
Authors: Cobbold JF; Department of Gastroenterology and Hepatology, and NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, UK. Electronic address: jeremy.cobbold@ouh.nhs.uk., Miller H; Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK., Hallsworth K; Liver Unit and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Manousou P; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK; Department of Hepatology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK., Marjot T; Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, UK; Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK., Allison MED; Liver Unit, Department of Medicine, Cambridge NIHR Biomedical Research Centre, Cambridge University NHS Foundation Trust, Cambridge, UK., Anstee QM; Liver Unit and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Armstrong MJ; Liver Transplant Unit, Queen Elizabeth University Hospital, Birmingham, UK., Avery L; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK; Centre for Population Health and Healthcare, School of Health and Life Sciences, Teesside University, Middlesbrough, UK., Azzu V; Liver Unit, Department of Medicine, Cambridge NIHR Biomedical Research Centre, Cambridge University NHS Foundation Trust, Cambridge, UK; Department of Gastroenterology and Hepatology, Norfolk and Norwich University Hospital, Norwich, UK., Brennan PN; Division of Molecular and Clinical Medicine, University of Dundee, Dundee, Scotland, UK., Byrne CD; Southampton National Institute For Health and Care Research Biomedical Research Centre, University Hospital Southampton and University of Southampton, Southampton, UK., Cacciottolo TM; MRC Laboratory of Medical Sciences, Imperial College London, London, UK., Corless L; Department of Gastroenterology, Hepatology and Endoscopy, Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom., Forton D; Department of Gastroenterology and Hepatology, St George's Hospital, London, UK., Hardy T; South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK., Hebditch V; British Liver Trust, Bournemouth, UK., Jarvis H; Population Heath Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK., Li W; Barts Liver Centre, Blizard Institute, Queen Mary University of London, London, UK., Mansour D; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK; Department of Gastroenterology and Hepatology Queen Elizabeth Hospital, Gateshead, UK., McPherson S; Liver Unit and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Miao Y; Department of Gastroenterology and Hepatology, and NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Morling J; Lifespan and Population Health, School of Medicine, University of Nottingham, Nottingham, UK., Mukhopadhya A; Department of Gastroenterology, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, UK., Mullish B; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK; Department of Hepatology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK., Parker R; Department of Hepatology, St James University Hospital, The Leeds Teaching Hospitals NHS Trust, Leeds, UK., Patanwala I; Manchester Royal Infirmary, Manchester, UK., Patel J; Department of Gastroenterology and Hepatology, Bedford Hospital, Bedford, UK., Pavlides M; Department of Gastroenterology and Hepatology, and NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, UK; Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Reinson T; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK., Rowe IA; Leeds Institute for Medical Research, University of Leeds, Leeds Liver Unit, St James's University Hospital, Leeds, UK., Saffioti F; Department of Gastroenterology and Hepatology, and NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, UK., Shaikh F; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Srivastava A; North Bristol NHS Trust, Bristol, UK., Than NN; Gastroenterology and Hepatology Department, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK., Tsochatzis E; University College London Institute for Liver and Digestive Health, Royal Free Hospital and University College London, London, UK., Volcek E; Northern Health and Social Care Trust, Antrim, UK., Tomlinson JW; Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK., Alazawi W; Barts Liver Centre, Blizard Institute, Queen Mary University of London, London, UK.
Source: The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2026 Jul; Vol. 11 (7), pp. 616-626. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article; Consensus Statement; Review
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101690683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-1253 (Electronic) NLM ISO Abbreviation: Lancet Gastroenterol Hepatol Subsets: MEDLINE
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  Data: The use of pharmacotherapies in non-cirrhotic metabolic dysfunction-associated steatohepatitis: a UK expert consensus.
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  Data: <searchLink fieldCode="AU" term="%22Cobbold+JF%22">Cobbold JF</searchLink>; Department of Gastroenterology and Hepatology, and NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, UK. Electronic address: jeremy.cobbold@ouh.nhs.uk.<br /><searchLink fieldCode="AU" term="%22Miller+H%22">Miller H</searchLink>; Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hallsworth+K%22">Hallsworth K</searchLink>; Liver Unit and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Manousou+P%22">Manousou P</searchLink>; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK; Department of Hepatology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Marjot+T%22">Marjot T</searchLink>; Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, UK; Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Allison+MED%22">Allison MED</searchLink>; Liver Unit, Department of Medicine, Cambridge NIHR Biomedical Research Centre, Cambridge University NHS Foundation Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Anstee+QM%22">Anstee QM</searchLink>; Liver Unit and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Armstrong+MJ%22">Armstrong MJ</searchLink>; Liver Transplant Unit, Queen Elizabeth University Hospital, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Avery+L%22">Avery L</searchLink>; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK; Centre for Population Health and Healthcare, School of Health and Life Sciences, Teesside University, Middlesbrough, UK.<br /><searchLink fieldCode="AU" term="%22Azzu+V%22">Azzu V</searchLink>; Liver Unit, Department of Medicine, Cambridge NIHR Biomedical Research Centre, Cambridge University NHS Foundation Trust, Cambridge, UK; Department of Gastroenterology and Hepatology, Norfolk and Norwich University Hospital, Norwich, UK.<br /><searchLink fieldCode="AU" term="%22Brennan+PN%22">Brennan PN</searchLink>; Division of Molecular and Clinical Medicine, University of Dundee, Dundee, Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Byrne+CD%22">Byrne CD</searchLink>; Southampton National Institute For Health and Care Research Biomedical Research Centre, University Hospital Southampton and University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Cacciottolo+TM%22">Cacciottolo TM</searchLink>; MRC Laboratory of Medical Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Corless+L%22">Corless L</searchLink>; Department of Gastroenterology, Hepatology and Endoscopy, Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Forton+D%22">Forton D</searchLink>; Department of Gastroenterology and Hepatology, St George's Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Hardy+T%22">Hardy T</searchLink>; South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.<br /><searchLink fieldCode="AU" term="%22Hebditch+V%22">Hebditch V</searchLink>; British Liver Trust, Bournemouth, UK.<br /><searchLink fieldCode="AU" term="%22Jarvis+H%22">Jarvis H</searchLink>; Population Heath Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Barts Liver Centre, Blizard Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Mansour+D%22">Mansour D</searchLink>; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK; Department of Gastroenterology and Hepatology Queen Elizabeth Hospital, Gateshead, UK.<br /><searchLink fieldCode="AU" term="%22McPherson+S%22">McPherson S</searchLink>; Liver Unit and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Miao+Y%22">Miao Y</searchLink>; Department of Gastroenterology and Hepatology, and NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Morling+J%22">Morling J</searchLink>; Lifespan and Population Health, School of Medicine, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Mukhopadhya+A%22">Mukhopadhya A</searchLink>; Department of Gastroenterology, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, UK.<br /><searchLink fieldCode="AU" term="%22Mullish+B%22">Mullish B</searchLink>; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK; Department of Hepatology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Parker+R%22">Parker R</searchLink>; Department of Hepatology, St James University Hospital, The Leeds Teaching Hospitals NHS Trust, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Patanwala+I%22">Patanwala I</searchLink>; Manchester Royal Infirmary, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Patel+J%22">Patel J</searchLink>; Department of Gastroenterology and Hepatology, Bedford Hospital, Bedford, UK.<br /><searchLink fieldCode="AU" term="%22Pavlides+M%22">Pavlides M</searchLink>; Department of Gastroenterology and Hepatology, and NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, UK; Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Reinson+T%22">Reinson T</searchLink>; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Rowe+IA%22">Rowe IA</searchLink>; Leeds Institute for Medical Research, University of Leeds, Leeds Liver Unit, St James's University Hospital, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Saffioti+F%22">Saffioti F</searchLink>; Department of Gastroenterology and Hepatology, and NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Shaikh+F%22">Shaikh F</searchLink>; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Srivastava+A%22">Srivastava A</searchLink>; North Bristol NHS Trust, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Than+NN%22">Than NN</searchLink>; Gastroenterology and Hepatology Department, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.<br /><searchLink fieldCode="AU" term="%22Tsochatzis+E%22">Tsochatzis E</searchLink>; University College London Institute for Liver and Digestive Health, Royal Free Hospital and University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Volcek+E%22">Volcek E</searchLink>; Northern Health and Social Care Trust, Antrim, UK.<br /><searchLink fieldCode="AU" term="%22Tomlinson+JW%22">Tomlinson JW</searchLink>; Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Alazawi+W%22">Alazawi W</searchLink>; Barts Liver Centre, Blizard Institute, Queen Mary University of London, London, UK.
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  Data: <searchLink fieldCode="JN" term="%22101690683%22">The lancet. Gastroenterology & hepatology</searchLink> [Lancet Gastroenterol Hepatol] 2026 Jul; Vol. 11 (7), pp. 616-626. <i>Date of Electronic Publication: </i>2026 Apr 30.
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