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Biotransformation of progesterone by Aspergillus welwitschiae CCMB 674 yields a novel metabolite 11α,21-dihydroxyprogesterone, alongside three known compounds.

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Title: Biotransformation of progesterone by Aspergillus welwitschiae CCMB 674 yields a novel metabolite 11α,21-dihydroxyprogesterone, alongside three known compounds.
Authors: Dutra LP; Departamento de Química (Instituto de Ciências Exatas), Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil., Oliveira MN; Departamento de Química (Instituto de Ciências Exatas), Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil., Dias de Souza ML; Departamento de Química (Instituto de Ciências Exatas), Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil., Duarte LP; Departamento de Química (Instituto de Ciências Exatas), Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil., de Pádua RM; Departamento de Produtos Farmacêuticos (Faculdade de Farmácia), Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil., Góes-Neto A; Departamento de Microbiologia (Instituto de Ciências Biológicas), Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil., Vidal DM; Departamento de Química (Instituto de Ciências Exatas), Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil; Departamento de Química, Universidade Federal do Paraná (UFPR), Av. Coronel H. dos Santos, 100, Curitiba, PR 81531-980, Brazil. Electronic address: vidal@ufpr.br.
Source: Steroids [Steroids] 2026 Jul-Aug; Vol. 231-232, pp. 109792. Date of Electronic Publication: 2026 May 01.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0404536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5867 (Electronic) Linking ISSN: 0039128X NLM ISO Abbreviation: Steroids Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Biotransformation of progesterone by Aspergillus welwitschiae CCMB 674 yields a novel metabolite 11α,21-dihydroxyprogesterone, alongside three known compounds.
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  Data: <searchLink fieldCode="AU" term="%22Dutra+LP%22">Dutra LP</searchLink>; Departamento de Química (Instituto de Ciências Exatas), Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil.<br /><searchLink fieldCode="AU" term="%22Oliveira+MN%22">Oliveira MN</searchLink>; Departamento de Química (Instituto de Ciências Exatas), Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil.<br /><searchLink fieldCode="AU" term="%22Dias+de+Souza+ML%22">Dias de Souza ML</searchLink>; Departamento de Química (Instituto de Ciências Exatas), Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil.<br /><searchLink fieldCode="AU" term="%22Duarte+LP%22">Duarte LP</searchLink>; Departamento de Química (Instituto de Ciências Exatas), Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Pádua+RM%22">de Pádua RM</searchLink>; Departamento de Produtos Farmacêuticos (Faculdade de Farmácia), Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil.<br /><searchLink fieldCode="AU" term="%22Góes-Neto+A%22">Góes-Neto A</searchLink>; Departamento de Microbiologia (Instituto de Ciências Biológicas), Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil.<br /><searchLink fieldCode="AU" term="%22Vidal+DM%22">Vidal DM</searchLink>; Departamento de Química (Instituto de Ciências Exatas), Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil; Departamento de Química, Universidade Federal do Paraná (UFPR), Av. Coronel H. dos Santos, 100, Curitiba, PR 81531-980, Brazil. Electronic address: vidal@ufpr.br.
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  Data: <searchLink fieldCode="JN" term="%220404536%22">Steroids</searchLink> [Steroids] 2026 Jul-Aug; Vol. 231-232, pp. 109792. <i>Date of Electronic Publication: </i>2026 May 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0404536 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1878-5867 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220039128X%22">0039128X </searchLink><i>NLM ISO Abbreviation: </i>Steroids <i>Subsets: </i>MEDLINE
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            – D: 01
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              Text: 2026 Jul-Aug
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              Y: 2026
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