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Efficacy, tolerability, and threshold effect of atropine eye drops for myopia control: A systematic review and dose-response meta-analysis.

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Title: Efficacy, tolerability, and threshold effect of atropine eye drops for myopia control: A systematic review and dose-response meta-analysis.
Authors: Zhang XJ; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Queen Mary Hospital, Pok Fu Lam, Hong Kong, China; Department of Ophthalmology, The Hong Kong University - Shenzhen Hospital, Shenzhen, China. Electronic address: hxjzhang@hku.hk., Liu M; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Yu M; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Eye-ACP, Duke-NUS Medical School, Singapore, Singapore., Ho ECF; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Wong RTC; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Zaabaar E; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Chen W; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Huang H; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Guo PY; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Department of Ophthalmology, The Hong Kong University - Shenzhen Hospital, Shenzhen, China., Sun J; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Lam AK; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Eye-ACP, Duke-NUS Medical School, Singapore, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Yam JC; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China., Shih KC; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Queen Mary Hospital, Pok Fu Lam, Hong Kong, China., Leung CKS MD, MB ChB; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Queen Mary Hospital, Pok Fu Lam, Hong Kong, China; Department of Ophthalmology, The Hong Kong University - Shenzhen Hospital, Shenzhen, China.
Source: Survey of ophthalmology [Surv Ophthalmol] 2026 May 01. Date of Electronic Publication: 2026 May 01.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 0404551 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3304 (Electronic) Linking ISSN: 00396257 NLM ISO Abbreviation: Surv Ophthalmol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy, tolerability, and threshold effect of atropine eye drops for myopia control: A systematic review and dose-response meta-analysis.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+XJ%22">Zhang XJ</searchLink>; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Queen Mary Hospital, Pok Fu Lam, Hong Kong, China; Department of Ophthalmology, The Hong Kong University - Shenzhen Hospital, Shenzhen, China. Electronic address: hxjzhang@hku.hk.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Yu+M%22">Yu M</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Eye-ACP, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ho+ECF%22">Ho ECF</searchLink>; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Wong+RTC%22">Wong RTC</searchLink>; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Zaabaar+E%22">Zaabaar E</searchLink>; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Guo+PY%22">Guo PY</searchLink>; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Department of Ophthalmology, The Hong Kong University - Shenzhen Hospital, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Sun+J%22">Sun J</searchLink>; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Lam+AK%22">Lam AK</searchLink>; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Cheng+CY%22">Cheng CY</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Eye-ACP, Duke-NUS Medical School, Singapore, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yam+JC%22">Yam JC</searchLink>; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Shih+KC%22">Shih KC</searchLink>; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Queen Mary Hospital, Pok Fu Lam, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Leung+CKS+MD%2C+MB+ChB%22">Leung CKS MD, MB ChB</searchLink>; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Queen Mary Hospital, Pok Fu Lam, Hong Kong, China; Department of Ophthalmology, The Hong Kong University - Shenzhen Hospital, Shenzhen, China.
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              Text: 2026 May 01
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