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Effects of α-synuclein pathology on synaptic dysfunction and clinical outcomes in normal aging.

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Title: Effects of α-synuclein pathology on synaptic dysfunction and clinical outcomes in normal aging.
Authors: Winer JR; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Plastini MJ; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Romero A; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Vossler H; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Sai I; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Channappa D; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Abdelnour C; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Shahid-Besanti M; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Wilson EN; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA., Oh HS; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Brain and Body Research Center of the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Young CB; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Department of Radiology, University of California Davis, Sacramento, California, USA.; Department of Neurology, University of California Davis, Sacramento, California, USA., Trelle A; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Yutsis M; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Sha SJ; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA., Ramirez V; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Taylor R; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Younes K; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Wyss-Coray T; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA., Greicius MD; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Henderson VW; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; Department of Epidemiology and Population Health, Stanford University, Stanford, California, USA., Wagner AD; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; Department of Psychology, Stanford University, Stanford, California, USA., Poston KL; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA., Mormino EC; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; Molecular Imaging Program at Stanford (MIPS), Stanford University, Stanford, California, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 May; Vol. 22 (5), pp. e71455.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
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  Data: Effects of α-synuclein pathology on synaptic dysfunction and clinical outcomes in normal aging.
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Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Young+CB%22">Young CB</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Department of Radiology, University of California Davis, Sacramento, California, USA.; Department of Neurology, University of California Davis, Sacramento, California, USA.<br /><searchLink fieldCode="AU" term="%22Trelle+A%22">Trelle A</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Yutsis+M%22">Yutsis M</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Sha+SJ%22">Sha SJ</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Ramirez+V%22">Ramirez V</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+R%22">Taylor R</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Younes+K%22">Younes K</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Wyss-Coray+T%22">Wyss-Coray T</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Greicius+MD%22">Greicius MD</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Henderson+VW%22">Henderson VW</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; Department of Epidemiology and Population Health, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Wagner+AD%22">Wagner AD</searchLink>; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; Department of Psychology, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Poston+KL%22">Poston KL</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Mormino+EC%22">Mormino EC</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; Molecular Imaging Program at Stanford (MIPS), Stanford University, Stanford, California, USA.
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